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Query: NC_003143:4105754:4128696 Yersinia pestis CO92, complete genome

Start: 4128696, End: 4129106, Length: 411

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:1729922:175286417528641753274411Yersinia pestis A1122 chromosome, complete genomenucleoside diphosphate kinase regulator4e-66249
NC_014029:4057696:408064640806464081056411Yersinia pestis Z176003 chromosome, complete genomenucleoside diphosphate kinase regulator4e-66249
NC_009708:483253:506237506237506647411Yersinia pseudotuberculosis IP 31758 chromosome, complete genomenucleoside diphosphate kinase regulator4e-66249
NC_009381:321577:344520344520344930411Yersinia pestis Pestoides F chromosome, complete genomenucleoside diphosphate kinase regulator4e-66249
NC_013166:82986:107723107723108133411Kangiella koreensis DSM 16069, complete genomeGreA/GreB family elongation factor2e-23107
NC_014623:6950638:695431569543156954749435Stigmatella aurantiaca DW4/3-1 chromosome, complete genometranscription elongation factor5e-2096.3
NC_016614:822715:840321840321840728408Vibrio sp. EJY3 chromosome 2, complete sequencenucleoside diphosphate kinase regulator2e-1787.8
NC_007519:1244198:126286712628671263280414Desulfovibrio alaskensis G20 chromosome, complete genomeGreA/GreB family elongation factor2e-1580.9
NC_007511:1147696:115267911526791153077399Burkholderia sp. 383 chromosome 2, complete sequenceGreA/GreB family elongation factor6e-1579.3
NC_010515:2691000:269403526940352694433399Burkholderia cenocepacia MC0-3 chromosome 2, complete sequenceGreA/GreB family elongation factor8e-1579
NC_011001:2085986:213958521395852139983399Burkholderia cenocepacia J2315 chromosome 2, complete sequenceputative transcription elongation factor8e-1579
NC_015410:2698572:270645827064582707378921Pseudomonas mendocina NK-01 chromosome, complete genomeacetyltransferase7e-1475.9
NC_004129:3965947:3973732397373239748711140Pseudomonas fluorescens Pf-5, complete genomeacetyltransferase, GNAT family family1e-1375.1
NC_014910:2585747:259558825955882596499912Alicycliphilus denitrificans BC chromosome, complete genomegcn5-related n-acetyltransferase4e-1373.2
NC_010172:3712000:372149237214923721863372Methylobacterium extorquens PA1, complete genometranscription elongation factor GreA/GreB domain protein7e-1269.3
NC_012808:3711806:372314737231473723470324Methylobacterium extorquens AM1, complete genomeputative transcription elongation factor (GreA/GreB domain protein)9e-1268.9
NC_012988:4075429:408741640874164087739324Methylobacterium extorquens DM4, complete genomeelongation factor, GreA/GreB family9e-1268.9
NC_009952:526456:544496544496544927432Dinoroseobacter shibae DFL 12, complete genomeGreA/GreB family elongation factor1e-1065.1
NC_012108:3824977:383744138374413837728288Desulfobacterium autotrophicum HRM2, complete genomeGreA23e-0960.5
NC_014972:480355:486589486589487002414Desulfobulbus propionicus DSM 2032 chromosome, complete genomeGreA/GreB family elongation factor1e-0755.5
NC_011894:7035285:704858370485837049026444Methylobacterium nodulans ORS 2060, complete genomeGreA/GreB family elongation factor1e-0652