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Query: NC_003143:4105754:4128086 Yersinia pestis CO92, complete genome

Start: 4128086, End: 4128472, Length: 387

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009381:321577:343910343910344296387Yersinia pestis Pestoides F chromosome, complete genomecytochrome2e-54210
NC_013592:1668092:168930416893041689681378Dickeya dadantii Ech586, complete genomecytochrome b5622e-1064.7
NC_012880:1765920:178566217856621786039378Dickeya dadantii Ech703, complete genomecytochrome b5629e-0648.9
NC_009708:483253:505627505627506013387Yersinia pseudotuberculosis IP 31758 chromosome, complete genomecytochrome b5622e-54210
NC_012912:1701231:174925417492541749631378Dickeya zeae Ech1591, complete genomecytochrome b5625e-1063.2
NC_017168:1729922:175225417522541752640387Yersinia pestis A1122 chromosome, complete genomeputative cytochrome2e-54210
NC_014029:4057696:408002840800284080414387Yersinia pestis Z176003 chromosome, complete genomeputative cytochrome2e-54210
NC_014500:3097362:309736230973623097739378Dickeya dadantii 3937 chromosome, complete genomeSoluble cytochrome b5623e-0960.8
NC_010611:3879190:7676465390Acinetobacter baumannii ACICU, complete genomesoluble cytochrome b5621e-0962