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Query: NC_003143:4105754:4127240 Yersinia pestis CO92, complete genome

Start: 4127240, End: 4127878, Length: 639

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011745:291422:297377297377298057681Escherichia coli ED1a chromosome, complete genomehypothetical protein3e-38158
AP010958:3853082:388902538890253889621597Escherichia coli O103:H2 str. 12009 DNA, complete genomehypothetical protein6e-49193
NC_013353:3853082:388902538890253889621597Escherichia coli O103:H2 str. 12009, complete genomehypothetical protein6e-49193
NC_007606:3842708:385915438591543859909756Shigella dysenteriae Sd197, complete genomehypothetical protein9e-69259
NC_017168:1729922:175143817514381752046609Yersinia pestis A1122 chromosome, complete genomehypothetical protein3e-117420
NC_017154:3997810:401932640193264019934609Yersinia pestis D106004 chromosome, complete genomehypothetical protein3e-117420
NC_009381:321577:343094343094343702609Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein3e-117420
NC_014029:4057696:407921240792124079820609Yersinia pestis Z176003 chromosome, complete genomehypothetical protein3e-117420
NC_009708:483253:504775504775505419645Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein3e-123440