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Query: NC_003143:4105754:4124916 Yersinia pestis CO92, complete genome

Start: 4124916, End: 4125464, Length: 549

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:1729922:174908417490841749632549Yersinia pestis A1122 chromosome, complete genomehypothetical protein3e-82303
NC_017154:3997810:401697240169724017520549Yersinia pestis D106004 chromosome, complete genomehypothetical protein3e-82303
NC_014029:4057696:407685840768584077406549Yersinia pestis Z176003 chromosome, complete genomehypothetical protein3e-82303
NC_009381:321577:340740340740341288549Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein3e-82303
NC_008150:4140804:415995641599564160504549Yersinia pestis Antiqua, complete genomehypothetical protein3e-82303
NC_009708:483253:502584502584503132549Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein5e-81299
NC_009655:866281:868881868881869426546Actinobacillus succinogenes 130Z chromosome, complete genomehypothetical protein2e-35148
NC_004347:4211241:423339742333974233930534Shewanella oneidensis MR-1, complete genomehypothetical protein4e-26117
NC_017505:841496:863533863533864045513Neisseria meningitidis alpha710 chromosome, complete genomehypothetical protein1e-21102
NC_017512:760000:780982780982781557576Neisseria meningitidis WUE 2594, complete genomehypothetical protein1e-21102
NC_015276:1947936:196596219659621966495534Marinomonas mediterranea MMB-1 chromosome, complete genomeUncharacterized protein family UPF03074e-21100
NC_010120:788000:809748809748810266519Neisseria meningitidis 053442, complete genomeconserved hypothetical protein6e-21100
NC_017517:867595:889554889554890060507Neisseria meningitidis M01-240355 chromosome, complete genomehypothetical protein1e-2099.8
NC_007973:2773427:279645927964592797067609Ralstonia metallidurans CH34 chromosome 1, complete sequenceprotein of unknown function DUF6154e-2097.8
NC_014910:1200605:120238812023881203056669Alicycliphilus denitrificans BC chromosome, complete genomehypothetical protein8e-1786.7