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Query: NC_003143:4105754:4124523 Yersinia pestis CO92, complete genome

Start: 4124523, End: 4124804, Length: 282

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:1729922:174869117486911748972282Yersinia pestis A1122 chromosome, complete genomeputative ribonuclease inhibitor1e-39161
NC_009708:483253:502207502207502488282Yersinia pseudotuberculosis IP 31758 chromosome, complete genomebarstar1e-39161
NC_009381:321577:340347340347340628282Yersinia pestis Pestoides F chromosome, complete genomeribonuclease inhibitor1e-39161
NC_008150:4140804:415956341595634159844282Yersinia pestis Antiqua, complete genomeputative ribonuclease inhibitor1e-39161
NC_013716:4824541:482807248280724828344273Citrobacter rodentium ICC168, complete genomehypothetical protein1e-1271.6
NC_012214:2019000:203967320396732039945273Erwinia pyrifoliae Ep1/96, complete genomeProbable ribonuclease inhibitor6e-0752.8