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Query: NC_003143:4105754:4124060 Yersinia pestis CO92, complete genome

Start: 4124060, End: 4124518, Length: 459

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:1729922:174821317482131748686474Yersinia pestis A1122 chromosome, complete genomeribonuclease5e-71266
NC_010465:522649:540921540921541394474Yersinia pseudotuberculosis YPIII, complete genomeguanine-specific ribonuclease N1 and T15e-71266
NC_008150:4140804:415908541590854159558474Yersinia pestis Antiqua, complete genomeputative ribonuclease5e-71266
NC_009381:321577:339869339869340342474Yersinia pestis Pestoides F chromosome, complete genomeribonuclease5e-71266
NC_009708:483253:501729501729502202474Yersinia pseudotuberculosis IP 31758 chromosome, complete genomeribonuclease Ba5e-71266
NC_014029:4057696:407598740759874076460474Yersinia pestis Z176003 chromosome, complete genomeribonuclease5e-71266
NC_017154:3997810:401610140161014016574474Yersinia pestis D106004 chromosome, complete genomeribonuclease5e-71266
NC_012214:2019000:203920120392012039671471Erwinia pyrifoliae Ep1/96, complete genomeRibonuclease3e-39160
UCMB5137:2128500:213982821398282140103276Bacillus atrophaeus UCMB-5137ribonuclease precursor (Barnase)1e-28125
NC_017505:670919:6756086756086775931986Neisseria meningitidis alpha710 chromosome, complete genomeMafB-like protein2e-1374.3