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Query: NC_003143:4105754:4119012 Yersinia pestis CO92, complete genome

Start: 4119012, End: 4119215, Length: 204

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:4171500:417502241750224175225204Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,membrane protein of efflux system1e-30131
NC_008150:4140804:415405241540524154255204Yersinia pestis Antiqua, complete genomehypothetical protein1e-30131
NC_005810:4381182:438581743858174386020204Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein1e-30131
NC_004088:179775:184075184075184278204Yersinia pestis KIM, complete genomehypothetical protein1e-30131
NC_008149:3966586:397088639708863971089204Yersinia pestis Nepal516, complete genomemembrane protein1e-30131
NC_010159:1208699:121334012133401213543204Yersinia pestis Angola, complete genomehypothetical protein1e-30131
NC_006155:4210606:421524242152424215445204Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein1e-30131
NC_010634:4150763:415539941553994155602204Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein1e-30131
NC_010465:522649:535887535887536090204Yersinia pseudotuberculosis YPIII, complete genomeprotein of unknown function DUF16561e-30131
NC_009381:321577:334836334836335039204Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein1e-30131
NC_009708:483253:496695496695496898204Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein1e-30131
NC_017168:1729922:174318017431801743383204Yersinia pestis A1122 chromosome, complete genomeefflux system membrane protein1e-30131
NC_015224:4028150:403105040310504031253204Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,hypothetical protein6e-22102