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Query: NC_003143:4105754:4113934 Yersinia pestis CO92, complete genome

Start: 4113934, End: 4116435, Length: 2502

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:4171500:4177802417780241803032502Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,insecticidal toxin complex subunit protein01667
NC_008149:3966586:3973666397366639761672502Yersinia pestis Nepal516, complete genomeinsecticial toxin01667
NC_010159:1208699:1216120121612012186212502Yersinia pestis Angola, complete genomehypothetical protein01667
NC_009381:321577:3297583297583322592502Yersinia pestis Pestoides F chromosome, complete genomeinsecticidal toxin01667
NC_014029:4057696:4065876406587640683772502Yersinia pestis Z176003 chromosome, complete genomeputative insecticial toxin01667
NC_017154:3997810:4005990400599040084912502Yersinia pestis D106004 chromosome, complete genomeputative insecticidal toxin01667
NC_017160:3986844:3993924399392439964252502Yersinia pestis D182038 chromosome, complete genomeputative insecticidal toxin01667
NC_017168:1729922:1738102173810217406032502Yersinia pestis A1122 chromosome, complete genomeputative insecticial toxin01667
NC_006155:4210606:4218022421802242205142493Yersinia pseudotuberculosis IP 32953, complete genomeputative insecticial toxin01596
NC_010634:4150763:4158179415817941606712493Yersinia pseudotuberculosis PB1/+, complete genomeputative virulence A protein01592
NC_010465:522649:5308095308095333102502Yersinia pseudotuberculosis YPIII, complete genomevirulence plasmid 28.1 kDa A protein01580
NC_004088:179775:1870321870321893562325Yersinia pestis KIM, complete genometoxin subunit01544
NC_005810:4381182:4388774438877443911042331Yersinia pestis biovar Microtus str. 91001, complete genomeputative insecticial toxin01540
NC_009708:483253:4914614914614941242664Yersinia pseudotuberculosis IP 31758 chromosome, complete genomeinsecticial toxin complex protein01466
NC_008150:4140804:4150177415017741514751299Yersinia pestis Antiqua, complete genomeputative insecticial toxin0875
NC_008150:4140804:4148985414898541502081224Yersinia pestis Antiqua, complete genomeputative insecticial toxin0785
NC_015224:4028150:4033686403368640358452160Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,putative insecticidal toxin complex protein2e-102374
NC_014718:232832:2605652605652638703306Burkholderia rhizoxinica HKI 454 chromosome, complete genomeInsecticidal toxin complex protein TcaA1e-57225
NC_007005:4992730:5000484500048450079927509Pseudomonas syringae pv. syringae B728a, complete genomeinsecticidal toxin complex protein TcdA13e-1378.2
NC_013892:1503162:1524551152455115321047554Xenorhabdus bovienii SS-2004 chromosome, complete genomeinsecticidal toxin complex (Tc) protein4e-1274.3
NC_016901:680870:7004817004817070746594Shewanella baltica OS678 chromosome, complete genomeinsecticidal toxin complex/plasmid viulence protein9e-1169.7
NC_009997:685726:7041007041007106936594Shewanella baltica OS195, complete genomehypothetical protein9e-1169.7
NC_010067:660659:6697546697546746734920Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein1e-0965.9