Pre_GI: BLASTP Hits

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Query: NC_003143:2258636:2277593 Yersinia pestis CO92, complete genome

Start: 2277593, End: 2278435, Length: 843

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017154:2258228:227718322771832278025843Yersinia pestis D106004 chromosome, complete genomehypothetical protein1e-167588
NC_008150:1543635:156259115625911563433843Yersinia pestis Antiqua, complete genomehypothetical protein1e-167588
NC_005810:2043730:206268720626872063529843Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein1e-167588
NC_008149:1669921:168887816888781689720843Yersinia pestis Nepal516, complete genomehypothetical protein1e-167588
NC_006155:2334122:235306623530662353908843Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein3e-166584
NC_010634:2252329:227127322712732272115843Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein1e-165582