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Query: NC_003143:2258636:2276689 Yersinia pestis CO92, complete genome

Start: 2276689, End: 2277384, Length: 696

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017154:2258228:227627922762792276974696Yersinia pestis D106004 chromosome, complete genomehypothetical protein6e-101366
NC_008150:1543635:156168715616871562382696Yersinia pestis Antiqua, complete genomehypothetical protein6e-101366
NC_008149:1669921:168797416879741688669696Yersinia pestis Nepal516, complete genomemembrane protein6e-101366
NC_005810:2043730:206178420617842062479696Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein6e-101366
NC_006155:2334122:235216423521642352859696Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein2e-100365
NC_010634:2252329:227037122703712271066696Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein2e-100365
NC_013592:2968500:298205129820512982737687Dickeya dadantii Ech586, complete genomehypothetical protein6e-78290
NC_021066:1712905:175058317505831751272690Raoultella ornithinolytica B6, complete genomehypothetical protein5e-43174
NC_013592:3212834:323117932311793231865687Dickeya dadantii Ech586, complete genomehypothetical protein2e-41169
NC_012225:787737:787737787737788330594Brachyspira hyodysenteriae WA1, complete genomehypothetical protein7e-25114
NC_008687:388262:404744404744405418675Paracoccus denitrificans PD1222 chromosome 2, complete sequencehypothetical protein9e-0960.5