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Query: NC_003143:2258636:2268167 Yersinia pestis CO92, complete genome

Start: 2268167, End: 2269072, Length: 906

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:2263347:226873722687372269642906Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein5e-175613
NC_010465:2428620:243535524353552436260906Yersinia pseudotuberculosis YPIII, complete genomehypothetical protein5e-175613
NC_005810:2043730:205326220532622054167906Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein5e-175613
NC_008149:1669921:167945216794521680357906Yersinia pestis Nepal516, complete genomehypothetical protein5e-175613
NC_004088:2541033:254777925477792548684906Yersinia pestis KIM, complete genomehypothetical protein5e-175613
NC_008150:1543635:155316515531651554070906Yersinia pestis Antiqua, complete genomehypothetical protein5e-175613
NC_010634:2252329:226186022618602262765906Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein5e-175613
NC_006155:2334122:234365323436532344558906Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein5e-175613
NC_009381:1258396:126437312643731265278906Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein5e-175613
NC_014029:2335021:234176723417672342672906Yersinia pestis Z176003 chromosome, complete genomehypothetical protein5e-175613
NC_017154:2258228:226775722677572268662906Yersinia pestis D106004 chromosome, complete genomehypothetical protein5e-175613
NC_009708:2392640:239938723993872400292906Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein1e-174612