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Query: NC_003143:2258636:2263734 Yersinia pestis CO92, complete genome

Start: 2263734, End: 2264372, Length: 639

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:2263347:227343722734372274075639Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,putative sugar-phosphate isomerase1e-122438
NC_010634:2252329:225742722574272258065639Yersinia pseudotuberculosis PB1/+, complete genomeribose/galactose isomerase1e-122438
NC_008150:1543635:154873315487331549371639Yersinia pestis Antiqua, complete genomeputative sugar-phosphate isomerase1e-122438
NC_005810:2043730:204882920488292049467639Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein1e-122438
NC_010465:2428620:244005424400542440692639Yersinia pseudotuberculosis YPIII, complete genomeRibose/galactose isomerase1e-122438
NC_006155:2334122:233922023392202339858639Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein1e-122438
NC_004088:2541033:255247925524792553117639Yersinia pestis KIM, complete genomehypothetical protein1e-122438
NC_008149:1669921:167501916750191675657639Yersinia pestis Nepal516, complete genomesugar-phosphate isomerase1e-122438
NC_009381:1258396:126907312690731269711639Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein1e-122438
NC_009708:2392640:240408724040872404725639Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein1e-122438
NC_014029:2335021:234646723464672347105639Yersinia pestis Z176003 chromosome, complete genomehypothetical protein1e-122438
NC_009655:1626466:163661316366131637254642Actinobacillus succinogenes 130Z chromosome, complete genomehypothetical protein1e-108391
NC_004460:973738:985323985323985958636Vibrio vulnificus CMCP6 chromosome II, complete sequencehypothetical protein5e-88323
NC_004431:279868:289106289106289744639Escherichia coli CFT073, complete genomehypothetical protein6e-79293
NC_005139:518760:530553530553531194642Vibrio vulnificus YJ016 chromosome I, complete sequencehypothetical protein6e-76283
NC_017154:2258228:226332622633262263736411Yersinia pestis D106004 chromosome, complete genomesugar-phosphate isomerase5e-68257
NC_010001:615427:622395622395623030636Clostridium phytofermentans ISDg, complete genomeRibose/galactose isomerase2e-63241
NC_009442:1158268:117012811701281170769642Streptococcus suis 05ZYH33 chromosome, complete genomehypothetical protein4e-63240
NC_012917:2921932:292512129251212925759639Pectobacterium carotovorum subsp. carotovorum PC1, complete genomeRibose/galactose isomerase5e-59227
NC_004547:1970686:198944019894401990078639Erwinia carotovora subsp. atroseptica SCRI1043, complete genomehypothetical protein6e-59226
NC_013592:1730505:175465617546561755294639Dickeya dadantii Ech586, complete genomeRibose/galactose isomerase7e-59226
NC_013421:3117639:312485131248513125489639Pectobacterium wasabiae WPP163, complete genomeRibose/galactose isomerase8e-59226
NC_012912:1788308:181736218173621818000639Dickeya zeae Ech1591, complete genomeRibose/galactose isomerase1e-54212
NC_014500:3023762:303036030303603030998639Dickeya dadantii 3937 chromosome, complete genomeGalactose-6-phosphate isomerase LacB subunit4e-54211