Pre_GI: BLASTP Hits

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Query: NC_003143:2258636:2261376 Yersinia pestis CO92, complete genome

Start: 2261376, End: 2263487, Length: 2112

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017154:2258228:2260968226096822630792112Yersinia pestis D106004 chromosome, complete genomehypothetical protein01424
NC_014029:2335021:2347352234735223494632112Yersinia pestis Z176003 chromosome, complete genomehypothetical protein01424
NC_008150:1543635:1546375154637515484862112Yersinia pestis Antiqua, complete genomehypothetical protein01424
NC_008149:1669921:1672661167266116747722112Yersinia pestis Nepal516, complete genomemembrane protein01422
NC_005810:2043730:2046471204647120485822112Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein01422
NC_004088:2541033:2553364255336425554752112Yersinia pestis KIM, complete genomehypothetical protein01422
NC_009381:1258396:1269958126995812720692112Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein01422
NC_017265:2263347:2274322227432222764332112Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein01422
NC_010465:2428620:2440939244093924430502112Yersinia pseudotuberculosis YPIII, complete genomeSel1 domain protein repeat-containing protein01415
NC_010634:2252329:2255069225506922571802112Yersinia pseudotuberculosis PB1/+, complete genomeSel1 domain-containing protein01414
NC_006155:2334122:2336862233686223389732112Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein01414
NC_009708:2392640:2404972240497224070832112Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein01410
NC_011149:2179592:2185324218532421874352112Salmonella enterica subsp. enterica serovar Agona str. SL483,hypothetical protein7e-121435
NC_011147:792489:8091688091688112792112Salmonella enterica subsp. enterica serovar Paratyphi A strhypothetical protein7e-120431
NC_006511:792543:8092228092228113332112Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCChypothetical protein7e-120431
NC_012125:1632150:1651174165117416532852112Salmonella enterica subsp. enterica serovar Paratyphi C strainhypothetical protein2e-119430
NC_004631:799810:8164208164208185312112Salmonella enterica subsp. enterica serovar Typhi Ty2, completehypothetical protein6e-119428
NC_003198:2179688:2185405218540521875162112Salmonella enterica subsp. enterica serovar Typhi str. CT18,hypothetical protein6e-119428
NC_016832:799764:8163748163748184852112Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12,hypothetical protein6e-119428
NC_006905:2235607:2239927223992722420382112Salmonella enterica subsp. enterica serovar Choleraesuis strputative inner membrane protein1e-118427
NC_008253:2198583:2203420220342022055282109Escherichia coli 536, complete genomehypothetical protein6e-112405
NC_004431:2444972:2452887245288724550342148Escherichia coli CFT073, complete genomehypothetical protein2e-111403