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Query: NC_003143:1880000:1898862 Yersinia pestis CO92, complete genome

Start: 1898862, End: 1900097, Length: 1236

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:1715035:1735298173529817365331236Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein0791
NC_014029:2607666:2608056260805626092911236Yersinia pestis Z176003 chromosome, complete genomehypothetical protein0791
NC_009381:2009842:2009842200984220110771236Yersinia pestis Pestoides F chromosome, complete genomemembrane protein0791
NC_005810:1976000:1995144199514419963791236Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein0791
NC_010159:2955562:295681929568192957442624Yersinia pestis Angola, complete genometransporter, MFS superfamily8e-116417
NC_010498:4967724:4967724496772449689921269Escherichia coli SMS-3-5, complete genomemajor facilitator family protein CglT4e-53209
NC_014364:3500041:3500041350004135013421302Spirochaeta smaragdinae DSM 11293 chromosome, complete genomemajor facilitator superfamily MFS_17e-47188
NC_009707:1811650:1813646181364618148991254Campylobacter jejuni subsp. doylei 269.97 chromosome, completemajor facilitator family protein5e-28125
NC_014624:3810163:3810163381016338114521290Eubacterium limosum KIST612 chromosome, complete genomemajor facilitator family protein4e-28125
NC_014802:1631483:1633479163347916347381260Campylobacter jejuni subsp. jejuni ICDCCJ07001 chromosome, completemajor facilitator family protein3e-27122
NC_014624:2297000:2304174230417423054511278Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein2e-25117
NC_014218:1485568:1503909150390915051861278Arcanobacterium haemolyticum DSM 20595 chromosome, complete genomemajor facilitator superfamily MFS_12e-25117
NC_014654:592582:6105296105296118271299Halanaerobium sp. 'sapolanicus' chromosome, complete genomemajor facilitator superfamily MFS_12e-25116
NC_012997:1820734:1869372186937218707331362Teredinibacter turnerae T7901, complete genomemajor facilitator family protein5e-24112
NC_012121:897866:9136769136769149861311Staphylococcus carnosus subsp. carnosus TM300, complete genomehypothetical protein9e-24111
NC_010336:733751:7373597373597386391281Francisella philomiragia subsp. philomiragia ATCC 25017, completemajor facilitator superfamily (MFS_1) transporter2e-1687.4
NC_021171:4588792:4604781460478146060311251Bacillus sp. 1NLA3E, complete genomemajor facilitator superfamily protein1e-1481.6