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Query: NC_003143:1691000:1701145 Yersinia pestis CO92, complete genome

Start: 1701145, End: 1703505, Length: 2361

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_004088:2937077:2944012294401229464892478Yersinia pestis KIM, complete genomehypothetical protein01441
NC_008149:2773139:2780191278019127825512361Yersinia pestis Nepal516, complete genomemembrane protein01439
NC_008150:905000:9150099150099173692361Yersinia pestis Antiqua, complete genomehypothetical protein01439
NC_005810:1520000:1530049153004915324092361Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein01439
NC_009381:1655731:1662783166278316651432361Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein01439
NC_017168:3948514:3955566395556639579262361Yersinia pestis A1122 chromosome, complete genomehypothetical protein01439
NC_017265:2557476:2564528256452825668882361Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein01439
NC_010634:1809500:1819373181937318217332361Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein01423
NC_006155:1807902:1819164181916418215242361Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein01423
NC_009708:2788855:2795909279590927982692361Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein01419
NC_010465:2820500:2826357282635728287172361Yersinia pseudotuberculosis YPIII, complete genomehypothetical protein01414
NC_017160:2054289:2061383206138320637012319Yersinia pestis D182038 chromosome, complete genomehypothetical protein01412
NC_017154:1707500:1717743171774317200612319Yersinia pestis D106004 chromosome, complete genomehypothetical protein01412
NC_014029:1760948:1775650177565017779682319Yersinia pestis Z176003 chromosome, complete genomehypothetical protein01412
NC_010159:3169266:3177448317744831796192172Yersinia pestis Angola, complete genomehypothetical protein01230
NC_015224:1703130:1714081171408117164892409Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,Membrane protein0870
NC_008800:3061484:3068765306876530711372373Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,hypothetical protein0840
NC_003228:1870953:1875353187535318777732421Bacteroides fragilis NCTC 9343, complete genomeputative FtsX-related transmembrane transport protein3e-0964.7
NC_016776:1878791:1879504187950418819242421Bacteroides fragilis 638R, complete genomeputative FtsX-related transmembrane transport protein5e-0963.9
NC_016609:1774259:1784624178462417870082385Niastella koreensis GR20-10 chromosome, complete genomehypothetical protein5e-0860.5
NC_015510:4905345:4906601490660149090362436Haliscomenobacter hydrossis DSM 1100 chromosome, complete genomehypothetical protein5e-0757