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Query: NC_002971:951102:965269 Coxiella burnetii RSA 493, complete genome

Start: 965269, End: 965568, Length: 300

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Causes Q-fever. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011527:953442:962254962254962553300Coxiella burnetii CbuG_Q212, complete genomenucleotidyltransferase2e-49194
NC_009727:1001203:100776910077691008068300Coxiella burnetii Dugway 7E9-12, complete genomeputative nucleotidyltransferase1e-48191
NC_011528:767940:773600773600773899300Coxiella burnetii CbuK_Q154, complete genomenucleotidyltransferase1e-48191
NC_009655:866281:889662889662889955294Actinobacillus succinogenes 130Z chromosome, complete genomeDNA polymerase subunit beta1e-1581.6
NC_008786:3323167:3357602335760233592511650Verminephrobacter eiseniae EF01-2, complete genomerestriction modification system DNA specificity domain2e-1580.9
NC_014963:4569015:4588149458814945900081860Terriglobus saanensis SP1PR4 chromosome, complete genomeamidophosphoribosyltransferase4e-1270.1