Pre_GI: BLASTP Hits

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Query: NC_002971:951102:963556 Coxiella burnetii RSA 493, complete genome

Start: 963556, End: 963912, Length: 357

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Causes Q-fever. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011528:767940:775256775256775525270Coxiella burnetii CbuK_Q154, complete genomehypothetical protein4e-41166
NC_009727:1001203:100942410094241009693270Coxiella burnetii Dugway 7E9-12, complete genomehypothetical protein1e-40164
NC_010184:3213347:322969032296903230049360Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein3e-1373.9
NC_015687:2632557:266576926657692666143375Clostridium acetobutylicum DSM 1731 chromosome, complete genomehypothetical protein8e-1269.3
NC_007508:1221500:123993512399351240315381Xanthomonas campestris pv. vesicatoria str. 85-10, complete genomehypothetical protein9e-1268.9
NC_009092:4337617:435068443506844351046363Shewanella loihica PV-4, complete genomehypothetical protein1e-1168.6
NC_016010:1169850:117344611734461173826381Xanthomonas axonopodis pv. citrumelo F1 chromosome, completehypothetical protein3e-1167
NC_008463:5246954:530348553034855303844360Pseudomonas aeruginosa UCBPP-PA14, complete genomehypothetical protein2e-0961.2