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Query: NC_002950:209569:229730 Porphyromonas gingivalis W83, complete genome

Start: 229730, End: 230254, Length: 525

Host Lineage: Porphyromonas gingivalis; Porphyromonas; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria

General Information: This strain (also known as HG66) is virulent in a mouse model and has been extensively studied. It was originally isolated by H. Werner in the 1950s in Bonn, Germany, from an unknown human infection. Associated with severe and chronic periodontal disease. This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin.Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015177:2271499:229194322919432292467525Pedobacter saltans DSM 12145 chromosome, complete genomeouter membrane chaperone Skp (OmpH)2e-29128
NC_013730:5372608:537532153753215375893573Spirosoma linguale DSM 74, complete genomeouter membrane chaperone Skp (OmpH)3e-1477.8
NC_015177:2271499:229138422913842291896513Pedobacter saltans DSM 12145 chromosome, complete genomeouter membrane chaperone Skp (OmpH)6e-0857
NC_013730:5372608:537591253759125376577666Spirosoma linguale DSM 74, complete genomeouter membrane chaperone Skp (OmpH)7e-0753.5