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Query: NC_002950:1571383:1578590 Porphyromonas gingivalis W83, complete genome

Start: 1578590, End: 1579189, Length: 600

Host Lineage: Porphyromonas gingivalis; Porphyromonas; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria

General Information: This strain (also known as HG66) is virulent in a mouse model and has been extensively studied. It was originally isolated by H. Werner in the 1950s in Bonn, Germany, from an unknown human infection. Associated with severe and chronic periodontal disease. This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin.Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015164:493159:515760515760516371612Bacteroides salanitronis DSM 18170 chromosome, complete genomeregulatory protein TetR8e-1270.5
NC_015164:3759959:376076637607663761377612Bacteroides salanitronis DSM 18170 chromosome, complete genomeregulatory protein TetR7e-1373.6
NC_015164:3759959:376919737691973769808612Bacteroides salanitronis DSM 18170 chromosome, complete genomeregulatory protein TetR5e-1374.3
NC_015164:3727500:374080537408053741416612Bacteroides salanitronis DSM 18170 chromosome, complete genomeregulatory protein TetR2e-1375.5
NC_015164:1208874:121001612100161210639624Bacteroides salanitronis DSM 18170 chromosome, complete genomeregulatory protein TetR2e-1065.5
NC_015311:1860666:188275018827501883376627Prevotella denticola F0289 chromosome, complete genomeTetR family transcriptional regulator1e-1376.3
NC_018515:3108755:313167231316723132274603Desulfosporosinus meridiei DSM 13257 chromosome, complete genometranscriptional regulator3e-0962
NC_015571:1030527:104049310404931041101609Porphyromonas gingivalis TDC60, complete genometranscriptional regulator, TetR family1e-1893.2
NC_011899:1437981:145036314503631450923561Halothermothrix orenii H 168, complete genometranscriptional regulator, TetR family4e-0754.7