Some Help

Query: NC_002942:2397952 Legionella pneumophila subsp. pneumophila str. Philadelphia 1,

Start: 2397952, End: 2416334, Length: 18383

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This strain is the isolate from the initial event of Legionellosis in Philadelphia, USA. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

Search Results with any or all of these Fields

Host Accession, e.g. NC_0123..Host Description, e.g. Clostri...
Host Lineage, e.g. archae, Proteo, Firmi...
Host Information, e.g. soil, Thermo, Russia

Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_006369:23380002338000236009922100Legionella pneumophila str. Lens, complete genome08340BLASTN svgBLASTP svg
NC_013861:36590943659094368253823445Legionella longbeachae NSW150, complete genome2e-34155BLASTN svgBLASTP svg
NC_013861:46950046950050109231593Legionella longbeachae NSW150, complete genome7e-31143BLASTN svgBLASTP svg
NC_014364:2246524*2246524228373637213Spirochaeta smaragdinae DSM 11293 chromosome, complete genome2e-0661.9BLASTN svgBLASTP svg