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Query: NC_002942:2397952:2407667 Legionella pneumophila subsp. pneumophila str. Philadelphia 1,

Start: 2407667, End: 2410288, Length: 2622

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This strain is the isolate from the initial event of Legionellosis in Philadelphia, USA. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016811:2359232:2369540236954023721612622Legionella pneumophila subsp. pneumophila ATCC 43290 chromosome,hypothetical protein01724
NC_014125:2463751:2476952247695224795792628Legionella pneumophila 2300/99 Alcoy chromosome, complete genomehypothetical protein01665
NC_009494:2477743:2490944249094424935712628Legionella pneumophila str. Corby chromosome, complete genomehypothetical protein01661
NC_006369:2338000:2351144235114423537682625Legionella pneumophila str. Lens, complete genomehypothetical protein01613