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Query: NC_002942:1109618:1112133 Legionella pneumophila subsp. pneumophila str. Philadelphia 1,

Start: 1112133, End: 1113392, Length: 1260

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This strain is the isolate from the initial event of Legionellosis in Philadelphia, USA. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_006368:2684358:2708819270881927100781260Legionella pneumophila str. Paris, complete genomeChemiosmotic efflux system B protein C0797
NC_008607:11663:2176721767231071341Pelobacter propionicus DSM 2379 plasmid pPRO1, complete sequenceouter membrane efflux protein4e-32139
NC_014315:1744485:1770060177006017715651506Nitrosococcus watsoni C-113 chromosome, complete genomeouter membrane efflux protein4e-29129
NC_007484:1671835:1691836169183616933411506Nitrosococcus oceani ATCC 19707, complete genomeOuter membrane efflux protein1e-28127
NC_020126:6264651:6264651626465162661171467Myxococcus stipitatus DSM 14675, complete genomecation efflux system protein CusC8e-27121
NC_018697:1343756:1359083135908313602911209Cycloclasticus sp. P1 chromosome, complete genomeOuter membrane efflux protein4e-26119
NC_016616:2768053:2789813278981327910841272Dechlorosoma suillum PS chromosome, complete genomeouter membrane protein7e-24112
NC_012483:1408500:1422174142217414234361263Acidobacterium capsulatum ATCC 51196, complete genomeouter membrane efflux protein1e-22107
NC_015740:2692023:2696797269679726980831287Pseudomonas stutzeri ATCC 17588 = LMG 11199 chromosome, completeouter membrane protein7e-22105
NC_016616:1091606:1104832110483211061031272Dechlorosoma suillum PS chromosome, complete genomeouter membrane protein1e-21104
NC_007484:1694738:1707773170777317091101338Nitrosococcus oceani ATCC 19707, complete genomeOuter membrane efflux protein2e-20100
NC_009434:3611738:3641791364179136430771287Pseudomonas stutzeri A1501, complete genomeouter membrane protein3e-2099.8
NC_014315:1744485:1750422175042217517591338Nitrosococcus watsoni C-113 chromosome, complete genomeouter membrane efflux protein6e-2099
NC_013960:1693643:1704390170439017057241335Nitrosococcus halophilus Nc4 chromosome, complete genomeouter membrane efflux protein7e-1995.1
NC_008782:2857899:2871796287179628730701275Acidovorax sp. JS42, complete genomeouter membrane efflux protein3e-1893.2
NC_011992:2279752:2325391232539123266651275Acidovorax ebreus TPSY, complete genomeouter membrane efflux protein9e-1788.6
NC_008782:1510000:1534916153491615361901275Acidovorax sp. JS42, complete genomeouter membrane efflux protein2e-1687.4
NC_015422:2858228:2873637287363728749111275Alicycliphilus denitrificans K601 chromosome, complete genomeouter membrane efflux protein2e-1687.4
NC_014394:738365:7534557534557547081254Gallionella capsiferriformans ES-2 chromosome, complete genomeouter membrane efflux protein1e-1584.7
NC_008347:174000:1846931846931859371245Maricaulis maris MCS10, complete genomeouter membrane protein1e-0964.7
NC_016599:513357:5199575199575211831227Owenweeksia hongkongensis DSM 17368 chromosome, complete genomeouter membrane protein2e-0963.9
NC_015914:3197772:3223483322348332247121230Cyclobacterium marinum DSM 745 chromosome, complete genomeouter membrane efflux protein4e-0963.2
NC_015638:328601:3439553439553451901236Lacinutrix sp. 5H-3-7-4 chromosome, complete genomeouter membrane efflux protein1e-0861.2
NC_016602:173314:1883521883521897161365Vibrio furnissii NCTC 11218 chromosome 1, complete sequenceouter membrane protein6e-0859.3
NC_015496:1288377:1304382130438213055991218Krokinobacter diaphorus 4H-3-7-5 chromosome, complete genomeouter membrane efflux protein7e-0858.9
NC_014759:2438492:2490830249083024920621233Marivirga tractuosa DSM 4126 chromosome, complete genomeouter membrane efflux protein1e-0758.5
NC_014041:3633842:3648293364829336495101218Zunongwangia profunda SM-A87 chromosome, complete genomeOuter membrane efflux protein2e-0757.4
NC_015856:3059737:3078129307812930795681440Collimonas fungivorans Ter331 chromosome, complete genometripartite multidrug resistance system outer membrane protein1e-0654.7
NC_008255:1701195:1732854173285417341251272Cytophaga hutchinsonii ATCC 33406, complete genomehypothetical protein3e-0653.5
NC_011206:2040000:2065582206558220668921311Acidithiobacillus ferrooxidans ATCC 53993, complete genomeouter membrane efflux protein4e-0653.1
NC_010170:4800000:4868326486832648696151290Bordetella petrii, complete genomemetal ion efflux outer membrane protein, putative8e-0652