Pre_GI: BLASTP Hits

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Query: NC_002755:831397:848300 Mycobacterium tuberculosis CDC1551, complete genome

Start: 848300, End: 850054, Length: 1755

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain, also nicknamed "Oshkosh", is a recent clinical isolate from a clothing factory worker from the Kentucky/Tennessee, USA, region. It is highly contagious, infecting approximately 80% of the patient's social contacts. However, this strain has not caused epidemics in man and is sensitive to a wide range of drugs. It is also highly virulent in a mouse lung model, producing several orders of magnitude more bacteria than the H37Rv strain when inoculated. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016804:831500:8482308482308499751746Mycobacterium bovis BCG str. Mexico chromosome, complete genomePE PGRS family protein3e-142505
NC_008769:860670:8779428779428796961755Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomePE-PGRS family protein3e-142505
NC_012207:831030:8483028483028500561755Mycobacterium bovis BCG str. Tokyo 172, complete genomePE-PGRS family protein3e-142505
NC_009565:833076:8500288500288517821755Mycobacterium tuberculosis F11, complete genomePE-PGRS family protein3e-142505
NC_002945:831029:8483498483498501031755Mycobacterium bovis AF2122/97, complete genomePE-PGRS family protein3e-142505
NC_012943:830000:8473578473578491111755Mycobacterium tuberculosis KZN 1435 chromosome, complete genomePE-PGRS family protein3e-142505
NC_016768:830000:8473618473618491151755Mycobacterium tuberculosis KZN 4207 chromosome, complete genomePE-PGRS family protein3e-142505
NC_009525:830513:8474748474748492191746Mycobacterium tuberculosis H37Ra, complete genomePE-PGRS family protein3e-142505
NC_009338:4869700:4870700487070048720311332Mycobacterium gilvum PYR-GCK chromosome, complete genomephosphoglycerate mutase2e-35151
NC_008769:3769065:379112937911293791839711Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative lipoprotein lpqD1e-1999
NC_009525:3794000:381354338135433814253711Mycobacterium tuberculosis H37Ra, complete genomeputative lipoprotein LpqD1e-1999
NC_000962:3781501:380486538048653805575711Mycobacterium tuberculosis H37Rv, complete genomePROBABLE CONSERVED LIPOPROTEIN LPQD1e-1999
NC_019950:3818000:383266838326683833378711Mycobacterium canettii CIPT 140060008 complete genomeConserved lipoprotein of unknown function, LpqD1e-1999
NC_009565:3793976:381598238159823816692711Mycobacterium tuberculosis F11, complete genomelipoprotein lpqD1e-1999
NC_002945:3735141:375720237572023757912711Mycobacterium bovis AF2122/97, complete genomelipoprotein LpqD1e-1999
NC_012207:3766978:378904237890423789752711Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative lipoprotein1e-1999
NC_002755:3773734:379574037957403796450711Mycobacterium tuberculosis CDC1551, complete genomelipoprotein, putative8e-2099
NC_017026:3754000:377412137741213774831711Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein1e-1999
NC_016804:3753243:377049437704943771204711Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative lipoprotein1e-1999
NC_016768:3774105:379611137961113796821711Mycobacterium tuberculosis KZN 4207 chromosome, complete genomelipoprotein LpqD1e-1999
NC_012943:3777371:379937737993773800087711Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein1e-1999
NC_015848:3851230:387219538721953872905711Mycobacterium canettii CIPT 140010059, complete genomeputative lipoprotein LPQD1e-1998.6
NC_017904:1683471:170965317096531710132480Mycobacterium sp. MOTT36Y chromosome, complete genomephosphoglycerate mutase family protein3e-1790.5
NC_018750:3741581:376592337659233766558636Streptomyces venezuelae ATCC 10712, complete genomeisomerase5e-1583.2
NC_008278:5855401:585655158565515857315765Frankia alni ACN14a, complete genome2,3-PDG dependent phosphoglycerate mutase3e-0860.5