Pre_GI: BLASTP Hits

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Query: NC_002755:831397:834723 Mycobacterium tuberculosis CDC1551, complete genome

Start: 834723, End: 835037, Length: 315

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain, also nicknamed "Oshkosh", is a recent clinical isolate from a clothing factory worker from the Kentucky/Tennessee, USA, region. It is highly contagious, infecting approximately 80% of the patient's social contacts. However, this strain has not caused epidemics in man and is sensitive to a wide range of drugs. It is also highly virulent in a mouse lung model, producing several orders of magnitude more bacteria than the H37Rv strain when inoculated. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:829444:833031833031833345315Mycobacterium tuberculosis RGTB327 chromosome, complete genometransposase2e-42170
NC_012207:831030:834359834359834673315Mycobacterium bovis BCG str. Tokyo 172, complete genometransposase2e-42170
NC_009565:833076:836403836403836717315Mycobacterium tuberculosis F11, complete genometransposase2e-42170
NC_002945:831029:834358834358834672315Mycobacterium bovis AF2122/97, complete genometransposase2e-42170
NC_009525:830513:833840833840834154315Mycobacterium tuberculosis H37Ra, complete genomeputative transposase2e-42170
NC_008769:860670:863999863999864313315Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative transposase2e-42170
NC_012943:830000:833534833534833848315Mycobacterium tuberculosis KZN 1435 chromosome, complete genometransposase2e-42170
NC_016768:830000:833538833538833852315Mycobacterium tuberculosis KZN 4207 chromosome, complete genometransposase2e-42170
NC_016804:831500:834278834278834592315Mycobacterium bovis BCG str. Mexico chromosome, complete genometransposase2e-42170
NC_015848:3851230:3869863386986338711971335Mycobacterium canettii CIPT 140010059, complete genometransposase for insertion sequence element is15571e-35147
NC_013131:9903320:9915279991527999165561278Catenulispora acidiphila DSM 44928, complete genometransposase IS204/IS1001/IS1096/IS1165 family protein1e-23108
NC_012803:1552122:1573850157385015749021053Micrococcus luteus NCTC 2665, complete genometransposase4e-22103
NC_012803:1094679:1102692110269211039541263Micrococcus luteus NCTC 2665, complete genometransposase5e-22102
NC_012803:1552122:1563481156348115647431263Micrococcus luteus NCTC 2665, complete genometransposase5e-22102
NC_014830:850542:8623978623978636591263Intrasporangium calvum DSM 43043 chromosome, complete genometransposase IS204/IS1001/IS1096/IS1165 family protein3e-21100
NC_014830:3870000:3883909388390938851711263Intrasporangium calvum DSM 43043 chromosome, complete genometransposase IS204/IS1001/IS1096/IS1165 family protein3e-21100
NC_014814:5422972:5426434542643454276571224Mycobacterium sp. Spyr1 chromosome, complete genometransposase family protein2e-0650.8