Pre_GI: BLASTP Hits

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Query: NC_002755:831397:832252 Mycobacterium tuberculosis CDC1551, complete genome

Start: 832252, End: 832800, Length: 549

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain, also nicknamed "Oshkosh", is a recent clinical isolate from a clothing factory worker from the Kentucky/Tennessee, USA, region. It is highly contagious, infecting approximately 80% of the patient's social contacts. However, this strain has not caused epidemics in man and is sensitive to a wide range of drugs. It is also highly virulent in a mouse lung model, producing several orders of magnitude more bacteria than the H37Rv strain when inoculated. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:829444:830559830559831107549Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein7e-80296
NC_012207:831030:831885831885832433549Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein7e-80296
NC_009565:833076:833931833931834479549Mycobacterium tuberculosis F11, complete genomehypothetical protein7e-80296
NC_002945:831029:831884831884832432549Mycobacterium bovis AF2122/97, complete genomehypothetical protein7e-80296
NC_008769:860670:861525861525862073549Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein7e-80296
NC_009525:830513:831368831368831916549Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein7e-80296
NC_012943:830000:831062831062831610549Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein7e-80296
NC_016768:830000:831066831066831614549Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein7e-80296
NC_016804:831500:831804831804832352549Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein7e-80296
NC_019673:1275627:128427212842721284847576Saccharothrix espanaensis DSM 44229 complete genomehypothetical protein1e-0653.1
NC_012522:4299287:431555143155514316534984Rhodococcus opacus B4, complete genomehypothetical protein1e-0652.8