Pre_GI: BLASTP Hits

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Query: NC_002755:2788000:2802153 Mycobacterium tuberculosis CDC1551, complete genome

Start: 2802153, End: 2802776, Length: 624

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain, also nicknamed "Oshkosh", is a recent clinical isolate from a clothing factory worker from the Kentucky/Tennessee, USA, region. It is highly contagious, infecting approximately 80% of the patient's social contacts. However, this strain has not caused epidemics in man and is sensitive to a wide range of drugs. It is also highly virulent in a mouse lung model, producing several orders of magnitude more bacteria than the H37Rv strain when inoculated. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:2786000:280029828002982800921624Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein2e-117421
NC_012207:2747599:276323427632342763857624Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein2e-117421
NC_008769:2754828:277046127704612771084624Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein2e-117421
NC_009525:2802987:281863328186332819256624Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein2e-117421
NC_002945:2757821:277346227734622774085624Mycobacterium bovis AF2122/97, complete genomehypothetical protein2e-117421
NC_000962:2791019:280666528066652807288624Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein2e-117421
NC_009565:2806000:281998328199832820606624Mycobacterium tuberculosis F11, complete genomehypothetical protein2e-117421
NC_016804:2735897:274982627498262750449624Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein2e-117421
NC_019950:2830682:284626328462632846886624Mycobacterium canettii CIPT 140060008 complete genomehypothetical protein7e-117419
NC_015848:2859145:287472628747262875349624Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein7e-117419
NC_016584:3617439:363985936398593640395537Desulfosporosinus orientis DSM 765 chromosome, complete genomehypothetical protein7e-1890.5
NC_015681:1201926:121619212161921216671480Thermodesulfatator indicus DSM 15286 chromosome, complete genomehypothetical protein8e-1787
NC_003552:3092456:311383631138363114345510Methanosarcina acetivorans C2A, complete genomehypothetical protein4e-1581.3
NC_020389:3106847:312501431250143125484471Methanosarcina mazei Tuc01, complete genomehypothetical protein3e-1478.2
NC_018870:2316499:231942623194262319938513Thermacetogenium phaeum DSM 12270 chromosome, complete genomehypothetical protein5e-1270.9
NC_007948:4558000:459129145912914591797507Polaromonas sp. JS666, complete genomelysine decarboxylase family protein2e-1065.9
NC_016629:3308329:334331733433173343784468Desulfovibrio africanus str. Walvis Bay chromosome, completehypothetical protein2e-0962.4
NC_008312:2349500:236189623618962362381486Trichodesmium erythraeum IMS101, complete genomeP450 cytochrome, putative3e-0961.6
NC_008554:3055000:305895930589593059435477Syntrophobacter fumaroxidans MPOB, complete genomehypothetical protein4e-0961.2
NC_006177:2883476:288646328864632887047585Symbiobacterium thermophilum IAM 14863, complete genomehypothetical protein1e-0860.1
NC_015672:2236000:225650522565052256963459Flexistipes sinusarabici DSM 4947 chromosome, complete genomehypothetical protein1e-0859.7
NC_014718:791528:799889799889800458570Burkholderia rhizoxinica HKI 454 chromosome, complete genomehypothetical protein3e-0858.5
NC_009828:1530732:153950415395041540028525Thermotoga lettingae TMO, complete genomehypothetical protein2e-0755.8
NC_013960:2166367:217875421787542179461708Nitrosococcus halophilus Nc4 chromosome, complete genomehypothetical protein3e-0651.6