Pre_GI: BLASTP Hits

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Query: NC_002755:1095105:1114837 Mycobacterium tuberculosis CDC1551, complete genome

Start: 1114837, End: 1115787, Length: 951

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain, also nicknamed "Oshkosh", is a recent clinical isolate from a clothing factory worker from the Kentucky/Tennessee, USA, region. It is highly contagious, infecting approximately 80% of the patient's social contacts. However, this strain has not caused epidemics in man and is sensitive to a wide range of drugs. It is also highly virulent in a mouse lung model, producing several orders of magnitude more bacteria than the H37Rv strain when inoculated. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:1095753:1115437111543711164381002Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein5e-171600
NC_016804:1095846:1115516111551611165171002Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein5e-171600
NC_002945:1095337:1115199111519911162001002Mycobacterium bovis AF2122/97, complete genomehypothetical protein5e-171600
NC_000962:1095078:1114748111474811157491002Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein5e-171600
NC_009525:1096386:1116056111605611170571002Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein5e-171600
NC_012207:1097228:1116898111689811178991002Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein5e-171600
NC_008769:1125567:1145237114523711462381002Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein5e-171600
NC_009565:1098847:1118516111851611195171002Mycobacterium tuberculosis F11, complete genomehypothetical protein5e-171600
NC_015848:1105892:1125549112554911265501002Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein1e-170598
NC_009380:1663545:1664806166480616674122607Salinispora tropica CNB-440 chromosome, complete genomeN-acetyltransferase GCN51e-1790.5
NC_010172:57500:582055820558726522Methylobacterium extorquens PA1, complete genomeGCN5-related N-acetyltransferase2e-1583.6
NC_011894:2359128:237323323732332373769537Methylobacterium nodulans ORS 2060, complete genomeGCN5-related N-acetyltransferase7e-1374.7
NC_015572:65597:861608616086798639Methylomonas methanica MC09 chromosome, complete genomeGCN5-like N-acetyltransferase1e-1274.3
NC_003296:87313:903229032290921600Ralstonia solanacearum GMI1000 plasmid pGMI1000MP, completehypothetical protein2e-0756.6
NC_015566:4205854:4206592420659242092402649Serratia sp. AS12 chromosome, complete genomeGCN5-like N-acetyltransferase5e-0755.5
NC_013595:5333000:5333032533303253356832652Streptosporangium roseum DSM 43021, complete genomeAcyl-CoA synthetase (NDP forming)-like protein1e-0653.9
NC_020211:4168189:4168927416892741715752649Serratia marcescens WW4, complete genomeinhibiting acetyltransferase for acetyl-CoA synthetase2e-0653.5
NC_007963:1190847:1234921123492112376022682Chromohalobacter salexigens DSM 3043, complete genomeGCN5-related N-acetyltransferase2e-0653.5
NC_008314:1825223:183783418378341838370537Ralstonia eutropha H16 chromosome 2, complete sequencehypothetical protein1e-0551.2