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Query: NC_002755:1095105:1108211 Mycobacterium tuberculosis CDC1551, complete genome

Start: 1108211, End: 1108564, Length: 354

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain, also nicknamed "Oshkosh", is a recent clinical isolate from a clothing factory worker from the Kentucky/Tennessee, USA, region. It is highly contagious, infecting approximately 80% of the patient's social contacts. However, this strain has not caused epidemics in man and is sensitive to a wide range of drugs. It is also highly virulent in a mouse lung model, producing several orders of magnitude more bacteria than the H37Rv strain when inoculated. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016768:3296478:330017633001763300529354Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein4e-40162
NC_012943:3299744:330344233034423303795354Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein4e-40162
NC_012207:1097228:111032211103221110654333Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical serine rich protein1e-35148
NC_000962:1095078:110817211081721108504333Mycobacterium tuberculosis H37Rv, complete genomeCONSERVED HYPOTHETICAL SERINE RICH PROTEIN1e-35148
NC_002945:1095337:110862311086231108955333Mycobacterium bovis AF2122/97, complete genomeputative serine rich protein1e-35148
NC_015848:1105892:111897911189791119311333Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein1e-35148
NC_008769:1125567:113866111386611138993333Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical serine rich protein1e-35148
NC_009525:1096386:110948011094801109812333Mycobacterium tuberculosis H37Ra, complete genomeconserved hypothetical serine rich protein1e-35148
NC_016804:1095846:110894011089401109272333Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein1e-35148
NC_017026:1095753:110885911088591109191333Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein1e-35148
NC_009565:1098847:111194011119401112272333Mycobacterium tuberculosis F11, complete genomeconserved serine rich protein1e-35148
NC_006361:5146000:517326351732635173559297Nocardia farcinica IFM 10152, complete genomehypothetical protein4e-24109
NC_017186:9120711:915325391532539153552300Amycolatopsis mediterranei S699 chromosome, complete genomehypothetical protein8e-2095.9
NC_021064:1789980:181078818107881811084297Propionibacterium avidum 44067, complete genomehypothetical protein1e-1582
NC_013174:2163947:216466921646692164872204Jonesia denitrificans DSM 20603, complete genomeregulatory protein, FmdB family4e-1476.6
NC_018750:3315309:331849333184933318774282Streptomyces venezuelae ATCC 10712, complete genomehypothetical protein8e-1268.9
NC_013525:1953920:196793619679361968187252Thermobaculum terrenum ATCC BAA-798 chromosome 1, complete genomeregulatory protein, FmdB family4e-1166.6
NC_009767:2734166:275094827509482751247300Roseiflexus castenholzii DSM 13941, complete genomeputative regulatory protein, FmdB family9e-1062.4
NC_015682:1457004:147401814740181474254237Thermodesulfobacterium sp. OPB45 chromosome, complete genomeFmdB family regulatory protein7e-1062.4
NC_014761:1588755:160341316034131603664252Oceanithermus profundus DSM 14977 chromosome, complete genomeregulatory protein, fmdb family3e-0857.4
NC_014640:6745873:679070167907016791021321Achromobacter xylosoxidans A8 chromosome, complete genomeregulatory protein, FmdB family domain-containing protein 24e-0650.1
NC_007912:1173752:117709811770981177334237Saccharophagus degradans 2-40, complete genomehypothetical protein4e-0650.1