Pre_GI: BLASTP Hits

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Query: NC_002755:1095105:1102581 Mycobacterium tuberculosis CDC1551, complete genome

Start: 1102581, End: 1105148, Length: 2568

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain, also nicknamed "Oshkosh", is a recent clinical isolate from a clothing factory worker from the Kentucky/Tennessee, USA, region. It is highly contagious, infecting approximately 80% of the patient's social contacts. However, this strain has not caused epidemics in man and is sensitive to a wide range of drugs. It is also highly virulent in a mouse lung model, producing several orders of magnitude more bacteria than the H37Rv strain when inoculated. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016768:3296478:3303592330359233061592568Mycobacterium tuberculosis KZN 4207 chromosome, complete genomeadhesion component transport transmembrane protein01506
NC_012943:3299744:3306858330685833094252568Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein01506
NC_000962:1095078:1102542110254211051092568Mycobacterium tuberculosis H37Rv, complete genomePROBABLE ADHESION COMPONENT TRANSPORT TRANSMEMBRANE PROTEIN ABC TRANSPORTER01506
NC_009565:1098847:1106310110631011088772568Mycobacterium tuberculosis F11, complete genomehypothetical adhesion component transport transmembrane protein ABC transporter01506
NC_009525:1096386:1103850110385011064172568Mycobacterium tuberculosis H37Ra, complete genomeadhesion component ABC transporter permease protein01506
NC_008769:1125567:1133031113303111355982568Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative adhesion component transport transmembrane protein ABC transporter01504
NC_012207:1097228:1104692110469211072592568Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative adhesion component transport transmembrane protein ABC transporter01504
NC_016804:1095846:1103310110331011058772568Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative adhesion component transport transmembrane protein ABC transporter01504
NC_015848:1105892:1113349111334911159162568Mycobacterium canettii CIPT 140010059, complete genomeputative adhesion component transport transmembrane protein ABC transporter01499
NC_017026:1095753:1104283110428311057911509Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein0890
NC_002945:1095337:1102993110299311042641272Mycobacterium bovis AF2122/97, complete genomeadhesion component transport transmembrane protein ABC transporter0755
NC_002945:1095337:1104265110426511055601296Mycobacterium bovis AF2122/97, complete genomeadhesion component transport transmembrane protein ABC transporter0750
NC_017026:1095753:110345111034511104254804Mycobacterium tuberculosis RGTB327 chromosome, complete genomeadhesion component transport transmembrane protein5e-124446
NC_013939:1902397:1899903189990319024042502Deferribacter desulfuricans SSM1, complete genomeABC transporter permease7e-52206
NC_009348:2738742:2740116274011627424642349Aeromonas salmonicida subsp. salmonicida A449, complete genomeABC-type transporter, permease protein2e-41171
NC_015733:3595882:3600131360013136025932463Pseudomonas putida S16 chromosome, complete genomehypothetical protein5e-27123
NC_011662:2402408:2420085242008524213111227Thauera sp. MZ1T, complete genomeprotein of unknown function DUF2145e-23110
NC_018750:3141196:3148639314863931511702532Streptomyces venezuelae ATCC 10712, complete genomeputative ABC transporter integral membrane protein8e-1996.3
NC_013929:8474195:8503623850362385061332511Streptomyces scabiei 87.22 chromosome, complete genomeABC transporter2e-1894.7
NC_007492:2310793:2311467231146723139142448Pseudomonas fluorescens PfO-1, complete genomeProtein of unknown function DUF2142e-1688.6
NC_008700:3514745:3518305351830535209232619Shewanella amazonensis SB2B, complete genomeputative ABC transport system permease protein4e-1584.3
NC_013739:2057781:2061313206131320638502538Conexibacter woesei DSM 14684, complete genomeprotein of unknown function DUF2142e-1275.1
NC_013595:1851226:1858595185859518611052511Streptosporangium roseum DSM 43021, complete genomeABC-type transport system involved in lysophospholipase L1 biosynthesis permease component-like protein2e-0965.1
NC_009952:3522370:3523424352342435258262403Dinoroseobacter shibae DFL 12, complete genomepredicted permease FtsX5e-0963.9
NC_015957:8816355:8828383882838388309142532Streptomyces violaceusniger Tu 4113 chromosome, complete genomehypothetical protein1e-0759.7
NC_014168:1294000:1322125132212513246142490Segniliparus rotundus DSM 44985 chromosome, complete genomehypothetical protein2e-0758.5
NC_015740:2614317:2643155264315526443751221Pseudomonas stutzeri ATCC 17588 = LMG 11199 chromosome, completelipoprotein release ABC transporter permease3e-0758.2