Pre_GI: BLASTP Hits

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Query: NC_000962:3474000:3492147 Mycobacterium tuberculosis H37Rv, complete genome

Start: 3492147, End: 3493181, Length: 1035

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain has been derived from the original human-lung H37 isolate in 1934, and has been used extensively worldwide in biomedical research. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:3466809:3486205348620534872391035Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein0662
NC_009525:3484924:3504303350430335053371035Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein0662
NC_002755:3465582:3487932348793234889781047Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein0662
NC_008769:3427254:3443857344385734448911035Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein0659
NC_002945:3429315:3445919344591934469531035Mycobacterium bovis AF2122/97, complete genomehypothetical protein0659
NC_012207:3421144:3436507343650734375411035Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein0659
NC_016804:3407859:3423222342322234242561035Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein0659
NC_006361:2920028:2936401293640129374021002Nocardia farcinica IFM 10152, complete genomehypothetical protein2e-50199
NC_013093:2633000:267178726717872672764978Actinosynnema mirum DSM 43827, complete genomenitroreductase1e-33143
NC_016887:3201976:322554132255413226338798Nocardia cyriacigeorgica GUH-2, complete genomehypothetical protein9e-32137
NC_013501:1140390:1158318115831811594031086Rhodothermus marinus DSM 4252, complete genomenitroreductase3e-24112
NC_012108:2220983:2266842226684222688812040Desulfobacterium autotrophicum HRM2, complete genomeputative dinucleotide-utilizing biosynthesis family protein (molybdopterin and thiamine biosynthesis family protein)8e-1065.1