Pre_GI: BLASTP Hits

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Query: NC_000962:3474000:3490476 Mycobacterium tuberculosis H37Rv, complete genome

Start: 3490476, End: 3491651, Length: 1176

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain has been derived from the original human-lung H37 isolate in 1934, and has been used extensively worldwide in biomedical research. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:3466809:3484534348453434857091176Mycobacterium tuberculosis RGTB327 chromosome, complete genomePPE family protein8e-152536
NC_009525:3484924:3502632350263235038071176Mycobacterium tuberculosis H37Ra, complete genomePPE family protein8e-152536
NC_009565:3485772:3503599350359935047741176Mycobacterium tuberculosis F11, complete genomePPE family protein8e-152536
NC_002755:3465582:3486273348627334874481176Mycobacterium tuberculosis CDC1551, complete genomePPE family protein8e-152536
NC_002945:3429315:3444248344424834454231176Mycobacterium bovis AF2122/97, complete genomePPE family protein2e-151535
NC_012207:3421144:343516334351633436011849Mycobacterium bovis BCG str. Tokyo 172, complete genomePPE family protein2e-105382
NC_008769:3427254:344251334425133443361849Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomePPE family protein2e-105382
NC_016804:3407859:342187834218783422726849Mycobacterium bovis BCG str. Mexico chromosome, complete genomePPE family protein2e-105382
NC_015848:2684275:2690027269002726912021176Mycobacterium canettii CIPT 140010059, complete genomePPE family protein8e-62238
NC_015848:2684275:2692091269209126932661176Mycobacterium canettii CIPT 140010059, complete genomePPE family protein8e-62238
NC_009525:2635792:2642827264282726440021176Mycobacterium tuberculosis H37Ra, complete genomePPE family protein5e-62238
NC_009525:2635792:2644891264489126460661176Mycobacterium tuberculosis H37Ra, complete genomePPE family protein5e-62238
NC_012943:1769445:1779051177905117802261176Mycobacterium tuberculosis KZN 1435 chromosome, complete genomePPE family protein5e-62238
NC_012943:1769445:1782493178249317836681176Mycobacterium tuberculosis KZN 1435 chromosome, complete genomePPE family protein5e-62238
NC_016768:1769332:1778938177893817801131176Mycobacterium tuberculosis KZN 4207 chromosome, complete genomePPE family protein5e-62238
NC_016768:1769332:1782380178238017835551176Mycobacterium tuberculosis KZN 4207 chromosome, complete genomePPE family protein5e-62238
NC_010612:4501414:4507776450777645089391164Mycobacterium marinum M, complete genomePPE family protein4e-61235
NC_010612:4501414:4509889450988945110551167Mycobacterium marinum M, complete genomePPE family protein2e-58226
NC_010612:5653031:5659834565983456688549021Mycobacterium marinum M, complete genomePPE family protein1e-35151
NC_010612:5301135:5316112531611253179771866Mycobacterium marinum M, complete genomePPE family protein1e-32140
NC_017904:3113000:3128391312839131295811191Mycobacterium sp. MOTT36Y chromosome, complete genomePPE family protein1e-32140
NC_016804:3407859:342155234215523421866315Mycobacterium bovis BCG str. Mexico chromosome, complete genomePPE family protein7e-31135
NC_012207:3421144:343483734348373435151315Mycobacterium bovis BCG str. Tokyo 172, complete genomePPE family protein7e-31135
NC_008769:3427254:344218734421873442501315Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomePPE family protein7e-31135
NC_017026:829444:8494948494948505491056Mycobacterium tuberculosis RGTB327 chromosome, complete genomePPE family protein2e-30133
NC_016768:830000:8493058493058512451941Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein2e-30133
NC_012943:830000:8493018493018512411941Mycobacterium tuberculosis KZN 1435 chromosome, complete genomePPE family protein2e-30133
NC_012207:831030:8502468502468521831938Mycobacterium bovis BCG str. Tokyo 172, complete genomePPE family protein3e-30132
NC_002945:831029:8502938502938522301938Mycobacterium bovis AF2122/97, complete genomePPE family protein3e-30132
NC_010612:6113155:6127439612743961290521614Mycobacterium marinum M, complete genomePPE family protein1e-28127
NC_017904:4742775:4742775474277547439621188Mycobacterium sp. MOTT36Y chromosome, complete genomePPE family protein3e-28126
NC_020133:5710661:5722718572271857243311614Mycobacterium liflandii 128FXT, complete genomePPE family protein4e-28125
NC_017904:4742775:4758520475852047596621143Mycobacterium sp. MOTT36Y chromosome, complete genomePPE family protein5e-25115
NC_010612:5301135:5318444531844453217643321Mycobacterium marinum M, complete genomePPE family protein6e-25115
NC_010612:5236229:5254885525488552560841200Mycobacterium marinum M, complete genomePPE family protein4e-23109
NC_020133:4841932:4855056485505648562491194Mycobacterium liflandii 128FXT, complete genomePPE family protein1e-22107
NC_010612:5236229:5253610525361052548031194Mycobacterium marinum M, complete genomePPE family protein2e-22107
NC_017904:4742775:4751684475168447529011218Mycobacterium sp. MOTT36Y chromosome, complete genomePPE family protein3e-22106
NC_010612:4501414:4513819451381945157441926Mycobacterium marinum M, complete genomePPE family protein2e-21103
NC_010612:4501414:4511619451161945135291911Mycobacterium marinum M, complete genomePPE family protein7e-21102
NC_002677:1380000:1381004138100413822691266Mycobacterium leprae TN, complete genomePPE-family protein1e-20101
NC_011896:1380000:1381044138104413822971254Mycobacterium leprae Br4923, complete genomePPE-family protein1e-20101
NC_016948:1074034:1077351107735110785051155Mycobacterium intracellulare MOTT-64 chromosome, complete genomehypothetical protein4e-1995.9
NC_017904:4742775:4756674475667447578071134Mycobacterium sp. MOTT36Y chromosome, complete genomePPE family protein4e-1582.8
NC_020133:4841932:4856376485637648575301155Mycobacterium liflandii 128FXT, complete genomePPE family protein6e-1582
NC_012207:2573562:2595923259592325973291407Mycobacterium bovis BCG str. Tokyo 172, complete genomePPE family protein1e-1378.2
NC_016768:1769332:1776640177664017785081869Mycobacterium tuberculosis KZN 4207 chromosome, complete genomePPE family protein2e-1377.4
NC_012943:1769445:1776753177675317786211869Mycobacterium tuberculosis KZN 1435 chromosome, complete genomePPE family protein2e-1377.4
NC_012943:1769445:1774168177416817760151848Mycobacterium tuberculosis KZN 1435 chromosome, complete genomePPE family protein8e-1375.1
NC_009525:2635792:2649656264965626515031848Mycobacterium tuberculosis H37Ra, complete genomePPE family protein8e-1375.1
NC_015848:2684275:2696301269630126981481848Mycobacterium canettii CIPT 140010059, complete genomePPE family protein8e-1375.1
NC_016768:1769332:1774055177405517759021848Mycobacterium tuberculosis KZN 4207 chromosome, complete genomePPE family protein8e-1375.1
NC_010612:5236229:5250659525065952520171359Mycobacterium marinum M, complete genomePPE family protein2e-1067
NC_002944:4147431:4159503415950341610171515Mycobacterium avium subsp. paratuberculosis K-10, complete genomehypothetical protein3e-1066.2
NC_008595:2546696:2546696254669625482821587Mycobacterium avium 104, complete genomePPE family protein5e-1065.9
NC_020133:4841932:4852270485227048534541185Mycobacterium liflandii 128FXT, complete genomePPE family protein1e-0964.7
NC_015848:2684275:2693696269369626955191824Mycobacterium canettii CIPT 140010059, complete genomeppe family protein1e-0758.2
NC_011896:491052:5087645087645099901227Mycobacterium leprae Br4923, complete genomeserine-rich antigen1e-0551.6