Pre_GI: BLASTP Hits

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Query: NC_000962:3474000:3489506 Mycobacterium tuberculosis H37Rv, complete genome

Start: 3489506, End: 3490375, Length: 870

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain has been derived from the original human-lung H37 isolate in 1934, and has been used extensively worldwide in biomedical research. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009565:3485772:350260535026053503498894Mycobacterium tuberculosis F11, complete genomehypothetical transcriptional regulatory protein8e-168589
NC_002755:3465582:348523734852373486172936Mycobacterium tuberculosis CDC1551, complete genometranscriptional regulator, AfsR/DnrI/RedD family2e-167588
NC_009525:3484924:350166235016623502531870Mycobacterium tuberculosis H37Ra, complete genomeputative transcriptional regulatory protein2e-167588
NC_002945:3429315:344327834432783444147870Mycobacterium bovis AF2122/97, complete genometranscriptional regulatory protein2e-167588
NC_016804:3407859:342058234205823421451870Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative transcriptional regulatory protein2e-166585
NC_008769:3427254:344121734412173442086870Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative transcriptional regulatory protein2e-166585
NC_012207:3421144:343386734338673434736870Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative transcriptional regulatory protein2e-166585
NC_017026:3466809:348378634837863484433648Mycobacterium tuberculosis RGTB327 chromosome, complete genometranscriptional regulator1e-121436
NC_009953:3509229:3521491352149135234551965Salinispora arenicola CNS-205 chromosome, complete genomeSARP family transcriptional regulator1e-36153
NC_013757:2659930:2674458267445826773312874Geodermatophilus obscurus DSM 43160, complete genometranscriptional regulator, winged helix family6e-30131
NC_008278:2732890:2752317275231727554123096Frankia alni ACN14a, complete genomeputative regulatory protein (AfsR-like protein)6e-30131
NC_013757:900500:9101879101879131893003Geodermatophilus obscurus DSM 43160, complete genometranscriptional regulator, SARP family7e-30131
NC_014666:4419693:4419693441969344229983306Frankia sp. EuI1c chromosome, complete genometranscriptional regulator, SARP family2e-29129
NC_009921:5787437:5806001580600158089402940Frankia sp. EAN1pec, complete genometranscriptional regulator, SARP family7e-27121
NC_013595:3712257:3727790372779037307052916Streptosporangium roseum DSM 43021, complete genometranscriptional regulator, SARP family3e-26119
NC_013595:4796436:4796436479643647994262991Streptosporangium roseum DSM 43021, complete genometranscriptional regulator, SARP family1e-25117
NC_013595:4758034:4774316477431647776603345Streptosporangium roseum DSM 43021, complete genomeATPase-like protein3e-25115
NC_013595:4031947:4052565405256540556573093Streptosporangium roseum DSM 43021, complete genometranscriptional regulator, SARP family1e-24114
NC_013093:7222000:7228008722800872311183111Actinosynnema mirum DSM 43827, complete genometranscriptional regulator, SARP family1e-24113
NC_015957:7408466:744725174472517448081831Streptomyces violaceusniger Tu 4113 chromosome, complete genomeSARP family transcriptional regulator5e-24111
NC_016582:6999074:7026400702640070305004101Streptomyces bingchenggensis BCW-1 chromosome, complete genomeAfsR-like regulatory protein5e-24111
NC_009953:4748147:4759217475921747610821866Salinispora arenicola CNS-205 chromosome, complete genomeSARP family transcriptional regulator8e-24110
NC_013235:5849659:5871616587161658748973282Nakamurella multipartita DSM 44233, complete genometranscriptional regulator, winged helix family5e-23108
NC_013947:1956923:1965214196521419679792766Stackebrandtia nassauensis DSM 44728 chromosome, complete genometranscriptional regulator, SARP family8e-23107
NC_018524:4848154:4849992484999248519711980Nocardiopsis alba ATCC BAA-2165 chromosome, complete genometranscriptional regulator, SARP family protein9e-23107
NC_016109:4199839:4211154421115442143213168Kitasatospora setae KM-6054, complete genomeputative AfsR family transcriptional regulator6e-22104
NC_014666:300571:324495324495325316822Frankia sp. EuI1c chromosome, complete genometranscriptional regulator, SARP family2e-21103
NC_020302:2116468:2137332213733221388551524Corynebacterium halotolerans YIM 70093 = DSM 44683, completeATPase-like protein2e-21102
NC_013093:626473:6338026338026366422841Actinosynnema mirum DSM 43827, complete genometranscriptional regulator, SARP family3e-21102
NC_018750:5078705:5093644509364450963372694Streptomyces venezuelae ATCC 10712, complete genomehypothetical protein4e-21102
NC_013595:3712257:3713298371329837163603063Streptosporangium roseum DSM 43021, complete genometranscriptional regulator, SARP family8e-21100
NC_016943:1314500:1314500131450013177873288Blastococcus saxobsidens DD2, complete genomeMulti-domain regulatory protein1e-20100
NC_013947:1570000:1577359157735915804423084Stackebrandtia nassauensis DSM 44728 chromosome, complete genometranscriptional regulator, SARP family3e-2099.4
NC_016109:6507076:6527002652700265300583057Kitasatospora setae KM-6054, complete genomeputative AfsR family transcriptional regulator4e-2098.6
NC_014815:2055286:2070183207018320734463264Micromonospora sp. L5 chromosome, complete genometranscriptional regulator, winged helix family5e-2098.2
NC_013757:1732747:1743495174349517463262832Geodermatophilus obscurus DSM 43160, complete genometranscriptional regulator, winged helix family2e-1996.7
NC_009142:6086000:6090748609074860943023555Saccharopolyspora erythraea NRRL 2338, complete genomehypothetical protein2e-1996.3
NC_003155:2211087:2212064221206422143222259Streptomyces avermitilis MA-4680, complete genomeregulatory protein2e-1996.3
NC_013947:460398:4835324835324866183087Stackebrandtia nassauensis DSM 44728 chromosome, complete genometranscriptional regulator, winged helix family4e-1995.5
NC_015656:2900730:291570029157002916479780Frankia symbiont of Datisca glomerata chromosome, complete genomeSARP family transcriptional regulator9e-1994.4
NC_017186:8588000:8595336859533685983953060Amycolatopsis mediterranei S699 chromosome, complete genomeSARP family transcriptional regulator1e-1893.6
NC_014318:8590078:8595280859528085983393060Amycolatopsis mediterranei U32 chromosome, complete genomeSARP family transcriptional regulator1e-1893.6
NC_015312:61752:7863778637814442808Pseudonocardia dioxanivorans CB1190 chromosome, complete genomewinged helix family transcriptional regulator2e-1892.8
NC_019673:6473743:6483586648358664864052820Saccharothrix espanaensis DSM 44229 complete genomeTranscriptional regulator, SARP family3e-1892.4
NC_019673:4687289:4697284469728447004093126Saccharothrix espanaensis DSM 44229 complete genomeProtein kinase2e-1789.7
NC_019673:1275627:1306946130694613101193174Saccharothrix espanaensis DSM 44229 complete genomehypothetical protein2e-1789.7
NC_008146:1535827:1535827153582715392523426Mycobacterium sp. MCS, complete genometranscriptional regulator, SARP family3e-1789.4
NC_008705:1537080:1540135154013515435603426Mycobacterium sp. KMS, complete genometranscriptional regulator, SARP family3e-1789.4
NC_019673:3253650:3276007327600732792493243Saccharothrix espanaensis DSM 44229 complete genomeATPase-like protein4e-1788.6
NC_013947:4413382:4426906442690644298572952Stackebrandtia nassauensis DSM 44728 chromosome, complete genometranscriptional regulator, SARP family5e-1788.6
NC_015953:5865733:586876158687615869573813Streptomyces sp. SirexAA-E chromosome, complete genomeSARP family transcriptional regulator1e-1687
NC_009953:5733211:574151357415135742403891Salinispora arenicola CNS-205 chromosome, complete genomeSARP family transcriptional regulator1e-1687
NC_015957:8816355:882305788230578823833777Streptomyces violaceusniger Tu 4113 chromosome, complete genome3e-1685.9
NC_017186:6539181:6543439654343965462282790Amycolatopsis mediterranei S699 chromosome, complete genomeSARP family transcriptional regulator6e-1685.1
NC_014318:6539137:6543395654339565461842790Amycolatopsis mediterranei U32 chromosome, complete genomeSARP family transcriptional regulator6e-1685.1
NC_013947:6678000:6692591669259166956953105Stackebrandtia nassauensis DSM 44728 chromosome, complete genometranscriptional regulator, SARP family7e-1684.7
NC_016109:7445603:7465978746597874689773000Kitasatospora setae KM-6054, complete genomeputative AfsR family transcriptional regulator2e-1479.7
NC_016111:3577572:3599142359914236023393198Streptomyces cattleya NRRL 8057, complete genomeAfsR-like regulatory protein3e-1376.3
NC_013729:380312:3858953858953878261932Kribbella flavida DSM 17836, complete genometranscriptional regulator, SARP family6e-1375.1
NC_013093:4522751:452275145227514523536786Actinosynnema mirum DSM 43827, complete genometranscriptional regulator, SARP family9e-1167.8
NC_013159:3858425:3858425385842538616073183Saccharomonospora viridis DSM 43017, complete genomepredicted ATPase2e-1066.6
NC_013947:5682895:5695664569566456984052742Stackebrandtia nassauensis DSM 44728 chromosome, complete genometranscriptional regulator, SARP family3e-0962.8
NC_015723:430165:4335914335914375383948Cupriavidus necator N-1 chromosome 2, complete sequenceadenylate/guanylate cyclase6e-0858.2
NC_013739:5535945:556073855607385561439702Conexibacter woesei DSM 14684, complete genome1e-0757.4
NC_014219:999648:1007214100721410083561143Bacillus selenitireducens MLS10 chromosome, complete genomeresponse regulator receiver and SARP domain protein1e-0653.9
NC_009483:2201986:224126822412682241900633Geobacter uraniireducens Rf4 chromosome, complete genomeSARP family transcriptional regulator4e-0652.4