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Query: NC_000962:3474000:3488569 Mycobacterium tuberculosis H37Rv, complete genome

Start: 3488569, End: 3489063, Length: 495

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain has been derived from the original human-lung H37 isolate in 1934, and has been used extensively worldwide in biomedical research. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016804:3407859:341964534196453420139495Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein2e-53207
NC_012207:3421144:343293034329303433424495Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein2e-53207
NC_008769:3427254:344028034402803440774495Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein2e-53207
NC_002945:3429315:344234134423413442835495Mycobacterium bovis AF2122/97, complete genomehypothetical protein2e-53207
NC_009525:3484924:350072535007253501219495Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein3e-53207
NC_009565:3485772:350170735017073502186480Mycobacterium tuberculosis F11, complete genomehypothetical protein1e-50198
NC_002755:3465582:348438134843813484860480Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein1e-50198
NC_017026:3466809:348267434826743483120447Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein2e-30131