Pre_GI: BLASTP Hits

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Query: NC_000962:3474000:3485572 Mycobacterium tuberculosis H37Rv, complete genome

Start: 3485572, End: 3486174, Length: 603

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain has been derived from the original human-lung H37 isolate in 1934, and has been used extensively worldwide in biomedical research. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:3466809:347962134796213480223603Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein5e-111399
NC_009525:3484924:349772834977283498330603Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein5e-111399
NC_009565:3485772:349869534986953499297603Mycobacterium tuberculosis F11, complete genomehypothetical protein5e-111399
NC_002755:3465582:348136934813693481971603Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein5e-111399
NC_012438:1564794:157778615777861578340555Sulfurihydrogenibium azorense Az-Fu1 chromosome, complete genometellurite resistance protein TehB1e-0963.5
NC_019974:1115553:117843011784301179047618Natronococcus occultus SP4, complete genomeTellurite resistance protein TehB1e-0859.3
NC_009943:1043210:106756910675691068120552Candidatus Desulfococcus oleovorans Hxd3, complete genomeTellurite resistance protein TehB4e-0754.7
NC_020126:7451894:745281274528127453408597Myxococcus stipitatus DSM 14675, complete genomethiopurine S-methyltransferase6e-0754.3