Pre_GI: BLASTP Hits

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Query: NC_000962:3474000:3479700 Mycobacterium tuberculosis H37Rv, complete genome

Start: 3479700, End: 3479951, Length: 252

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain has been derived from the original human-lung H37 isolate in 1934, and has been used extensively worldwide in biomedical research. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:3466809:347374434737443473995252Mycobacterium tuberculosis RGTB327 chromosome, complete genomemolybdenum cofactor biosynthesis protein D1e-42171
NC_002755:3465582:347549734754973475748252Mycobacterium tuberculosis CDC1551, complete genomemolybdenum cofactor biosynthesis protein D1e-42171
NC_002945:3429315:343624834362483436499252Mycobacterium bovis AF2122/97, complete genomemolybdenum cofactor biosynthesis protein D1e-42171
NC_012207:3421144:342683734268373427088252Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative molybdenum cofactor biosynthesis protein D1e-42171
NC_009525:3484924:349185634918563492107252Mycobacterium tuberculosis H37Ra, complete genomemolybdenum cofactor biosynthesis protein D11e-42171
NC_008769:3427254:343418734341873434438252Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative molybdenum cofactor biosynthesis protein D moaD11e-42171
NC_009565:3485772:349146534914653491716252Mycobacterium tuberculosis F11, complete genomemolybdenum cofactor biosynthesis protein D moaD11e-42171
NC_016804:3407859:341355234135523413803252Mycobacterium bovis BCG str. Mexico chromosome, complete genomemolybdenum cofactor biosynthesis protein D1e-42171
NC_012438:50845:707207072070962243Sulfurihydrogenibium azorense Az-Fu1 chromosome, complete genomehypothetical protein6e-0959.7
NC_009376:2102536:211667921166792117365687Pyrobaculum arsenaticum DSM 13514 chromosome, complete genomeMoaD family protein9e-0855.5
NC_016885:2091918:216835121683512169037687Pyrobaculum oguniense TE7 chromosome, complete genomeMoaD family protein, archaeal9e-0855.5
NC_003364:402268:403769403769404458690Pyrobaculum aerophilum str. IM2, complete genomemolybdenum cofactor biosynthesis protein D/E6e-0753.1