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Query: NC_000962:3474000:3478779 Mycobacterium tuberculosis H37Rv, complete genome

Start: 3478779, End: 3479174, Length: 396

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain has been derived from the original human-lung H37 isolate in 1934, and has been used extensively worldwide in biomedical research. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002755:3465582:347454334745433474971429Mycobacterium tuberculosis CDC1551, complete genomepterin-4-alpha-carbinolamine dehydratase1e-73274
NC_017026:3466809:347282334728233473218396Mycobacterium tuberculosis RGTB327 chromosome, complete genomepterin-4-alpha-carbinolamine dehydratase2e-73273
NC_016804:3407859:341263134126313413026396Mycobacterium bovis BCG str. Mexico chromosome, complete genomePterin-4-alpha-carbinolamine dehydratase2e-73273
NC_009525:3484924:349093534909353491330396Mycobacterium tuberculosis H37Ra, complete genomepterin-4-alpha-carbinolamine dehydratase MoaB12e-73273
NC_009565:3485772:349054434905443490939396Mycobacterium tuberculosis F11, complete genomepterin-4-alpha-carbinolamine dehydratase moaB12e-73273
NC_012207:3421144:342591634259163426311396Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative pterin-4-alpha-carbinolamine dehydratase2e-73273
NC_008769:3427254:343326634332663433661396Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative pterin-4-alpha-carbinolamine dehydratase moaB12e-73273
NC_002945:3429315:343532734353273435722396Mycobacterium bovis AF2122/97, complete genomepterin-4-alpha-carbinolamine dehydratase MoaB12e-73273
NC_009481:1638394:165646916564691656750282Synechococcus sp. WH 7803 chromosome, complete genomeputative pterin-4-alpha-carbinolamine dehydratase1e-0858.5
NC_008148:2053467:207059520705952070918324Rubrobacter xylanophilus DSM 9941, complete genometranscriptional coactivator/pterin dehydratase1e-0858.5
NC_020210:2044944:206551320655132065803291Geobacillus sp. GHH01, complete genometranscriptional activator1e-0858.5
NC_016002:2453919:245578324557832456112330Pseudogulbenkiania sp. NH8B, complete genomepterin-4-alpha-carbinolamine dehydratase8e-0855.8
NC_017271:2449504:246981924698192470175357Xanthomonas campestris pv. raphani 756C chromosome, completeputative pterin-4-alpha-carbinolamine dehydratase2e-0754.3
NC_007940:1485006:150411515041151504456342Rickettsia bellii RML369-C, complete genomePutative pterin-4-alpha-carbinolamine dehydratase3e-0650.8
NC_009883:1492425:151102315110231511364342Rickettsia bellii OSU 85-389, complete genomePutative pterin-4-alpha-carbinolamine dehydratase3e-0650.8
NC_013510:1023348:102637910263791026687309Thermomonospora curvata DSM 43183, complete genometranscriptional coactivator/pterin dehydratase4e-0650.1