Pre_GI: BLASTP Hits

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Query: NC_000962:3474000:3475378 Mycobacterium tuberculosis H37Rv, complete genome

Start: 3475378, End: 3476961, Length: 1584

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain has been derived from the original human-lung H37 isolate in 1934, and has been used extensively worldwide in biomedical research. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016804:3407859:3409230340923034108131584Mycobacterium bovis BCG str. Mexico chromosome, complete genomealkyldihydroxyacetonephosphate synthase0899
NC_008769:3427254:3429865342986534314481584Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative alkyldihydroxyacetonephosphate synthase agpS0899
NC_009565:3485772:3487143348714334887261584Mycobacterium tuberculosis F11, complete genomealkyldihydroxyacetonephosphate synthase agpS0899
NC_002945:3429315:3431926343192634335091584Mycobacterium bovis AF2122/97, complete genomealkyldihydroxyacetonephosphate synthase AgpS0899
NC_009525:3484924:3487534348753434891171584Mycobacterium tuberculosis H37Ra, complete genomealkyldihydroxyacetonephosphate synthase AgpS0899
NC_012207:3421144:3422515342251534240981584Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative alkyldihydroxyacetonephosphate synthase0899
NC_002755:3465582:3471175347117534727581584Mycobacterium tuberculosis CDC1551, complete genomealkyl-dihydroxyacetonephosphate synthase, putative0899
NC_009380:3563421:3578766357876635803731608Salinispora tropica CNB-440 chromosome, complete genomeFAD linked oxidase domain-containing protein3e-163575
NC_009953:3852436:3868554386855438701641611Salinispora arenicola CNS-205 chromosome, complete genomeFAD linked oxidase domain-containing protein3e-163575
NC_016943:4799915:4821215482121548227951581Blastococcus saxobsidens DD2, complete genomeFAD linked oxidase4e-132471
NC_015314:89815:9812198121997461626Pseudonocardia dioxanivorans CB1190 plasmid pPSED01, completeAlkylglycerone-phosphate synthase6e-127454
NC_010676:2658495:2705635270563527072391605Burkholderia phytofirmans PsJN chromosome 2, complete sequenceFAD linked oxidase domain protein2e-106387
NC_014834:614890:6501286501286517801653Rhodopseudomonas palustris DX-1 chromosome, complete genomeFAD linked oxidase domain-containing protein4e-100365
NC_020126:7896447:7896447789644778983421896Myxococcus stipitatus DSM 14675, complete genomeFAD linked oxidase8e-36152
NC_009828:1530732:1530732153073215324411710Thermotoga lettingae TMO, complete genomeFAD linked oxidase domain protein1e-33144
NC_012883:695652:7065837065837079801398Thermococcus sibiricus MM 739, complete genomeAlkyldihydroxyacetonephosphate synthase3e-30133
NC_010001:4128034:4146977414697741487161740Clostridium phytofermentans ISDg, complete genomeFAD linked oxidase domain protein2e-28127
NC_016885:1732257:1747611174761117489571347Pyrobaculum oguniense TE7 chromosome, complete genomeFAD/FMN-containing dehydrogenase2e-25117
NC_014624:828943:8355378355378369671431Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein2e-22107
NC_014654:592582:6087916087916102931503Halanaerobium sp. 'sapolanicus' chromosome, complete genomeAlkylglycerone-phosphate synthase7e-1995.9
NC_006510:2044347:2059856205985620612651410Geobacillus kaustophilus HTA426, complete genomeglycolate oxidase subunit2e-1687.8
NC_015436:1758257:1780777178077717821921416Spirochaeta coccoides DSM 17374 chromosome, complete genomeD-lactate dehydrogenase (cytochrome)7e-1685.9
NC_017276:320000:3343853343853357281344Sulfolobus islandicus REY15A chromosome, complete genomeFAD linked oxidase domain-containing protein3e-1584
NC_008699:2294361:2303931230393123052861356Nocardioides sp. JS614, complete genomeD-lactate dehydrogenase (cytochrome)3e-1583.6
NC_013854:2714033:2716318271631827177331416Azospirillum sp. B510, complete genomeFAD/FMN-containing dehydrogenases8e-1582.4
NC_013209:2384826:2384826238482623862531428Acetobacter pasteurianus IFO 3283-01, complete genomeD-Lactate dehydrogenase9e-1582
NC_017100:2383487:2386033238603323874601428Acetobacter pasteurianus IFO 3283-03, complete genomeD-Lactate dehydrogenase9e-1582
NC_017108:2383370:2383370238337023847971428Acetobacter pasteurianus IFO 3283-12, complete genomeD-Lactate dehydrogenase9e-1582
NC_017111:2383388:2383388238338823848151428Acetobacter pasteurianus IFO 3283-32, complete genomeD-Lactate dehydrogenase9e-1582
NC_017121:2383375:2383375238337523848021428Acetobacter pasteurianus IFO 3283-07, complete genomeD-Lactate dehydrogenase9e-1582
NC_017125:2383467:2386013238601323874401428Acetobacter pasteurianus IFO 3283-22, complete genomeD-Lactate dehydrogenase9e-1582
NC_017146:2383509:2386055238605523874821428Acetobacter pasteurianus IFO 3283-26, complete genomeD-Lactate dehydrogenase9e-1582
NC_017150:2290681:2292572229257222939991428Acetobacter pasteurianus IFO 3283-01-42C, complete genomeD-Lactate dehydrogenase9e-1582
NC_012622:327821:3371743371743385291356Sulfolobus islandicus Y.G.57.14 chromosome, complete genomeFAD linked oxidase domain-containing protein2e-1480.9
NC_014831:2082304:2110694211069421126761983Thermaerobacter marianensis DSM 12885 chromosome, complete genomeFAD linked oxidase domain protein3e-1480.5
NC_012623:2369671:2373007237300723743621356Sulfolobus islandicus Y.N.15.51 chromosome, complete genomeFAD linked oxidase domain-containing protein3e-1480.5
NC_013769:316789:3308183308183321731356Sulfolobus islandicus L.D.8.5 chromosome, complete genomeD-lactate dehydrogenase3e-1480.5
NC_015145:3236445:3272686327268632740561371Arthrobacter phenanthrenivorans Sphe3 chromosome, complete genomeglycolate oxidase subunit GlcD5e-1479.7
NC_003911:633393:6561466561466575431398Silicibacter pomeroyi DSS-3, complete genomeoxidoreductase, FAD-binding2e-1377.8
NC_016027:346768:3636443636443650981455Gluconacetobacter xylinus NBRC 3288, complete genomeD-Lactate dehydrogenase4e-1376.6
NC_010125:3393368:3414558341455834160271470Gluconacetobacter diazotrophicus PAl 5, complete genomeputative D-lactate dehydrogenase6e-1376.3
NC_011830:4645453:4651433465143346528121380Desulfitobacterium hafniense DCB-2, complete genomeD-lactate dehydrogenase (cytochrome)2e-1274.7
NC_015387:1002955:1017029101702910183751347Marinithermus hydrothermalis DSM 14884 chromosome, complete genomeD-lactate dehydrogenase (cytochrome)2e-1274.3
NC_015499:1466794:1475394147539414768001407Thermodesulfobium narugense DSM 14796 chromosome, complete genomeD-lactate dehydrogenase (cytochrome)6e-1272.8
NC_020911:3076791:3081892308189230833131422Octadecabacter antarcticus 307, complete genomeputative D-lactate dehydrogenase6e-1272.8
NC_018000:1852691:1874853187485318763101458Sinorhizobium fredii USDA 257 chromosome, complete genomeglycolate oxidase subunit GlcD8e-1272.4
NC_010794:1476494:1494414149441414958051392Methylacidiphilum infernorum V4, complete genomeGlycolate dehydrogenase subunit GlcD2e-1171.2
NC_010674:370629:3706293706293720321404Clostridium botulinum B str. Eklund 17B, complete genomeFAD/FMN-containing dehydrogenase4e-1169.7
NC_011894:585637:5856375856375870551419Methylobacterium nodulans ORS 2060, complete genomeFAD linked oxidase domain protein1e-1068.9
NC_014311:1635408:1659710165971016611221413Ralstonia solanacearum PSI07 chromosome, complete genomelactate dehydrogenase1e-1068.6
NC_010674:1390473:1398740139874014001761437Clostridium botulinum B str. Eklund 17B, complete genomeoxidase, FAD-binding1e-1068.6
NC_015687:2632557:2651829265182926532321404Clostridium acetobutylicum DSM 1731 chromosome, complete genomeFAD/FMN-containing dehydrogenase1e-1068.6
NC_003030:2630931:2650203265020326516061404Clostridium acetobutylicum ATCC 824, complete genomeFAD/FMN-containing dehydrogenase1e-1068.6
NC_017295:2630179:2649449264944926508521404Clostridium acetobutylicum EA 2018 chromosome, complete genomeFAD/FMN-containing dehydrogenase1e-1068.6
NC_014834:614890:6401306401306415661437Rhodopseudomonas palustris DX-1 chromosome, complete genomeFAD linked oxidase domain-containing protein2e-1068.2
NC_014758:1387470:1406337140633714077161380Calditerrivibrio nitroreducens DSM 19672 chromosome, completefad linked oxidase domain protein2e-1067.8
NC_010723:1379256:1389943138994313913791437Clostridium botulinum E3 str. Alaska E43, complete genomeoxidase, FAD-binding2e-1067.8
NC_008595:1349579:1370245137024513716121368Mycobacterium avium 104, complete genomeoxidoreductase, FAD-binding2e-1067.8
NC_009253:389835:3908653908653922711407Desulfotomaculum reducens MI-1 chromosome, complete genomeFAD linked oxidase domain-containing protein2e-1067.8
NC_014831:2082304:2093372209337220947511380Thermaerobacter marianensis DSM 12885 chromosome, complete genomeFAD linked oxidase domain protein2e-1067.8
NC_010003:123297:1328391328391342571419Petrotoga mobilis SJ95, complete genomeFAD linked oxidase domain protein3e-1067.4
NC_011283:1811000:1857329185732918586841356Klebsiella pneumoniae 342 chromosome, complete genomeoxidase, FAD-binding6e-1066.2
NC_015731:402280:4175584175584189311374Nitrosomonas sp. Is79A3 chromosome, complete genomeFAD linked oxidase domain-containing protein6e-1066.2
NC_017275:2615814:2633123263312326361253003Sulfolobus islandicus HVE10/4 chromosome, complete genomeFAD linked oxidase domain-containing protein8e-1065.9
NC_010520:1146000:1165186116518611665831398Clostridium botulinum A3 str. Loch Maree, complete genomeputative glycolate oxidase8e-1065.9
NC_002754:1968668:1986907198690719899093003Sulfolobus solfataricus P2, complete genomeDehydrogenase, putative7e-1065.9
NC_015850:2451957:2468581246858124700501470Acidithiobacillus caldus SM-1 chromosome, complete genomeglycolate dehydrogenase subunit GlcD7e-1065.9
NC_017276:2481083:2500916250091625039183003Sulfolobus islandicus REY15A chromosome, complete genomeFAD linked oxidase domain-containing protein6e-1065.9
NC_014206:3391352:3405264340526434066251362Geobacillus sp. C56-T3 chromosome, complete genomeFAD linked oxidase1e-0965.5
NC_012726:2549813:2564717256471725677193003Sulfolobus islandicus M.16.4 chromosome, complete genomeFAD linked oxidase domain-containing protein1e-0965.5
NC_006677:1255079:1277697127769712791031407Gluconobacter oxydans 621H, complete genomePutative lactate dehydrogenase9e-1065.5
NC_012623:2774910:2790237279023727932393003Sulfolobus islandicus Y.N.15.51 chromosome, complete genomeFAD linked oxidase domain-containing protein9e-1065.5
NC_009699:1122000:1135055113505511364521398Clostridium botulinum F str. Langeland chromosome, complete genomeglycolate oxidase9e-1065.5
NC_012632:2654200:2670471267047126734733003Sulfolobus islandicus M.16.27 chromosome, complete genomeFAD linked oxidase domain-containing protein9e-1065.5
NC_003295:1654000:1672034167203416734461413Ralstonia solanacearum GMI1000, complete genomePROBABLE OXIDOREDUCTASE PROTEIN9e-1065.5
NC_011891:3369170:3370396337039633718621467Anaeromyxobacter dehalogenans 2CP-1, complete genomeD-lactate dehydrogenase (cytochrome)8e-1065.5
NC_007643:889755:9286959286959301431449Rhodospirillum rubrum ATCC 11170, complete genomeD-lactate dehydrogenase (cytochrome)1e-0965.1
NC_009617:3360990:3366532336653233679591428Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeFAD linked oxidase domain-containing protein1e-0965.1
NC_008268:3418000:3421935342193534233051371Rhodococcus sp. RHA1, complete genomeprobable D-lactate dehydrogenase (cytochrome)1e-0964.7
NC_015658:319296:3356423356423388363195Halopiger xanaduensis SH-6 plasmid pHALXA01, complete sequenceD-lactate dehydrogenase (cytochrome)2e-0964.3
NC_014328:2518081:2542973254297325443551383Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative FAD/FMN-containing dehydrogenase2e-0964.3
NC_015275:4577642:4588652458865245900161365Clostridium lentocellum DSM 5427 chromosome, complete genomeD-lactate dehydrogenase (cytochrome)2e-0964.3
NC_008025:669281:6692816692816707291449Deinococcus geothermalis DSM 11300, complete genomeFAD linked oxidase-like protein2e-0964.3
NC_015859:1631573:1631573163157316329401368Corynebacterium variabile DSM 44702 chromosome, complete genomeoxidoreductase5e-0963.2
NC_012589:2698556:2714345271434527173473003Sulfolobus islandicus L.S.2.15, complete genomeFAD linked oxidase domain protein5e-0963.2
NC_013769:2685000:2700105270010527031073003Sulfolobus islandicus L.D.8.5 chromosome, complete genomeFAD linked oxidase domain-containing protein5e-0963.2
NC_012108:946314:9655979655979669701374Desulfobacterium autotrophicum HRM2, complete genomeGlcD14e-0963.2
NC_017179:1239991:1239991123999112413821392Clostridium difficile BI1, complete genomeFAD/FMN-containing dehydrogenase9e-0962.4
NC_013315:1230214:1230214123021412316051392Clostridium difficile CD196 chromosome, complete genomeFAD/FMN-containing dehydrogenase9e-0962.4
NC_013316:1225797:1227830122783012292211392Clostridium difficile R20291, complete genomeputative FAD/FMN-containing dehydrogenase9e-0962.4
NC_010524:3302398:3321035332103533224591425Leptothrix cholodnii SP-6, complete genomeFAD linked oxidase domain protein9e-0962.4
NC_010577:1456909:1476773147677314781611389Xylella fastidiosa M23, complete genomeFAD linked oxidase domain protein1e-0862
NC_004757:1089057:1096562109656210979291368Nitrosomonas europaea ATCC 19718, complete genomeD-lactate dehydrogenase1e-0861.6
NC_010513:1443787:1462870146287014642581389Xylella fastidiosa M12 chromosome, complete genomeoxidoreductase2e-0861.2
NC_018681:5378197:5409649540964954110101362Nocardia brasiliensis ATCC 700358 chromosome, complete genomefad linked oxidase domain-containing protein2e-0861.2
NC_015733:3595882:3617787361778736192861500Pseudomonas putida S16 chromosome, complete genomeglycolate oxidase, GlcD subunit2e-0860.8
NC_015169:1:1979919799211991401Deinococcus proteolyticus MRP plasmid pDEIPR01, complete sequenceD-lactate dehydrogenase (cytochrome)3e-0860.8
NC_008786:18688:3591335913373251413Verminephrobacter eiseniae EF01-2, complete genomeFAD linked oxidase domain protein3e-0860.5
NC_004431:3513147:3541181354118135426801500Escherichia coli CFT073, complete genomeGlycolate oxidase subunit glcD4e-0860.1
NC_009376:420000:4372904372904387051416Pyrobaculum arsenaticum DSM 13514 chromosome, complete genomeD-lactate dehydrogenase7e-0859.3
NC_018524:4988810:4994343499434349957101368Nocardiopsis alba ATCC BAA-2165 chromosome, complete genomeFAD linked oxidase, C-terminal domain protein7e-0859.3
NC_003364:756813:7568137568137582401428Pyrobaculum aerophilum str. IM2, complete genomeglycolate oxidase subunit glcD6e-0859.3
NC_014722:1084616:1110430111043011118751446Burkholderia rhizoxinica HKI 454, complete genomeFAD/FMN-containing dehydrogenases1e-0758.9
NC_007503:1111457:1155204115520411565801377Carboxydothermus hydrogenoformans Z-2901, complete genomeglycolate oxidase, GlcD subunit1e-0758.5
NC_015856:3436951:3451363345136334527751413Collimonas fungivorans Ter331 chromosome, complete genomeputative oxidoreductase1e-0758.5
NC_009440:1045882:1045882104588210472401359Metallosphaera sedula DSM 5348 chromosome, complete genomeD-lactate dehydrogenase1e-0758.2
NC_019792:3446895:3490376349037634934623087Natronobacterium gregoryi SP2 chromosome, complete genomeFAD/FMN-dependent dehydrogenase1e-0758.2
NC_015183:2483653:2488164248816424895521389Agrobacterium sp. H13-3 chromosome, complete genomeFAD linked oxidase-like protein3e-0757.4
NC_015976:3118804:3142008314200831434561449Sphingobium sp. SYK-6, complete genomeputative dehydrogenase/oxidoreductase3e-0757.4
NC_016885:1614427:1616573161657316179851413Pyrobaculum oguniense TE7 chromosome, complete genomeFAD/FMN-containing dehydrogenase3e-0757.4
NC_012489:209016:2326132326132340131401Gemmatimonas aurantiaca T-27, complete genomeFAD linked oxidase3e-0757
NC_003364:756813:755833755833756816984Pyrobaculum aerophilum str. IM2, complete genomeglycolate oxidase subunit glcE6e-0756.2
NC_009376:420000:438702438702439685984Pyrobaculum arsenaticum DSM 13514 chromosome, complete genomeFAD linked oxidase domain-containing protein8e-0755.8
NC_016885:1614427:161559316155931616576984Pyrobaculum oguniense TE7 chromosome, complete genomeFAD/FMN-containing dehydrogenase1e-0655.5
NC_014540:2828299:2854805285480528561931389Burkholderia sp. CCGE1003 chromosome 2, complete sequenceFAD linked oxidase domain-containing protein9e-0755.5
NC_014328:2203437:2213403221340322148091407Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative FAD/FMN-containing dehydrogenase1e-0655.1
NC_013124:1107202:1129004112900411303891386Acidimicrobium ferrooxidans DSM 10331, complete genomeFAD linked oxidase domain protein2e-0654.7
NC_008702:1094663:1103397110339711048031407Azoarcus sp. BH72, complete genomeputative glycolate oxidase subunit GlcD6e-0652.8
NC_016948:2129335:2130002213000221313871386Mycobacterium intracellulare MOTT-64 chromosome, complete genomeputative dehydrogenase7e-0652.8
NC_016947:2210339:2210339221033922117241386Mycobacterium intracellulare MOTT-02 chromosome, complete genomeputative dehydrogenase8e-0652.4
NC_017904:2162045:2162045216204521634301386Mycobacterium sp. MOTT36Y chromosome, complete genomedehydrogenase8e-0652.4