Pre_GI: BLASTP Hits

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Query: NC_000962:3474000:3474007 Mycobacterium tuberculosis H37Rv, complete genome

Start: 3474007, End: 3475377, Length: 1371

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain has been derived from the original human-lung H37 isolate in 1934, and has been used extensively worldwide in biomedical research. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:3466809:3468050346805034694201371Mycobacterium tuberculosis RGTB327 chromosome, complete genomeNADPH:adrenodoxin oxidoreductase fprA0891
NC_009565:3485772:3485772348577234871421371Mycobacterium tuberculosis F11, complete genomeNADPH:adrenodoxin oxidoreductase fprA0891
NC_002755:3465582:3469804346980434711741371Mycobacterium tuberculosis CDC1551, complete genomeferredoxin--NADP reductase0891
NC_009525:3484924:3486163348616334875331371Mycobacterium tuberculosis H37Ra, complete genomeferredoxin--NADP reductase0891
NC_008769:3427254:3428494342849434298641371Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative NADPH:adrenodoxin oxidoreductase fprA0888
NC_002945:3429315:3430555343055534319251371Mycobacterium bovis AF2122/97, complete genomeNADPH:adrenodoxin oxidoreductase FprA0888
NC_012207:3421144:3421144342114434225141371Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative NADPH:adrenodoxin oxidoreductase0888
NC_016804:3407859:3407859340785934092291371Mycobacterium bovis BCG str. Mexico chromosome, complete genomeNADPH-ferredoxin reductase0888
NC_011896:781500:8019858019858033551371Mycobacterium leprae Br4923, complete genomeputative NADPH-ferredoxin reductase0733
NC_012526:1502975:1522815152281515241851371Deinococcus deserti VCD115, complete genomeputative Ferredoxin--NADP(+) reductase (NADPH:adrenodoxin oxidoreductase)2e-92339
NC_018581:1718023:1726620172662017283111692Gordonia sp. KTR9 chromosome, complete genomeNADPH-dependent glutamate synthase beta chain-related oxidoreductase6e-87321
NC_017904:1763015:1779497177949717811131617Mycobacterium sp. MOTT36Y chromosome, complete genome4Fe-4S ferredoxin2e-85317
NC_015673:289578:3177163177163191401425Corynebacterium resistens DSM 45100 chromosome, complete genomeferredoxin/ferredoxin-NADP reductase2e-80300
NC_020302:2829484:2836700283670028381121413Corynebacterium halotolerans YIM 70093 = DSM 44683, completeferredoxin/ferredoxin--NADP reductase2e-80300
NC_015683:2249949:2249949224994922513011353Corynebacterium ulcerans BR-AD22 chromosome, complete genomeferredoxin/ferredoxin-NADP reductase8e-77288
NC_017317:2149794:2149794214979421511461353Corynebacterium ulcerans 809 chromosome, complete genomeferredoxin/ferredoxin-NADP reductase1e-76287
NC_006958:2911711:2911711291171129130781368Corynebacterium glutamicum ATCC 13032, complete genomePUTATIVE FERREDOXIN/FERREDOXIN-NADP REDUCTASE1e-76287
NC_003450:2938404:2938404293840429397711368Corynebacterium glutamicum ATCC 13032, complete genomeputative ferredoxin/ferredoxin-NADP reductase1e-76287
NC_013174:601434:6041196041196055101392Jonesia denitrificans DSM 20603, complete genomeFerredoxin--NADP(+) reductase3e-73276
NC_014643:1251847:1256971125697112583741404Rothia dentocariosa ATCC 17931 chromosome, complete genomeferredoxin-NADP reductase3e-72273
NC_016786:2059564:2061195206119520625531359Corynebacterium diphtheriae HC01 chromosome, complete genomeputative ferredoxin/ferredoxin-NADP reductase4e-72272
NC_016782:2058967:2060598206059820619561359Corynebacterium diphtheriae 241 chromosome, complete genomeputative ferredoxin/ferredoxin-NADP reductase4e-72272
NC_002935:2103677:2105308210530821066661359Corynebacterium diphtheriae NCTC 13129, complete genomePutative ferredoxin/ferredoxin-NADP reductase5e-72271
NC_010545:2025000:2041850204185020433131464Corynebacterium urealyticum DSM 7109, complete genomeputative ferredoxin/ferredoxin-NADP reductase3e-71269
NC_014151:4021394:4065641406564140670351395Cellulomonas flavigena DSM 20109 chromosome, complete genomeFAD-dependent pyridine nucleotide-disulfide oxidoreductase2e-70267
NC_006087:177375:1784551784551798251371Leifsonia xyli subsp. xyli str. CTCB07, complete genomeferredoxin/ferredoxin-NADP reductase4e-68259
NC_007947:577315:5838105838105851771368Methylobacillus flagellatus KT, complete genomeFAD-dependent pyridine nucleotide-disulphide oxidoreductase4e-68259
NC_014638:148527:1509261509261523411416Bifidobacterium bifidum PRL2010 chromosome, complete genomeferredoxin--NADP reductase1e-63244
NC_014616:169311:1716301716301730811452Bifidobacterium bifidum S17 chromosome, complete genomeferredoxin--NADP reductase9e-64244
NC_008268:7576365:7592358759235875937611404Rhodococcus sp. RHA1, complete genomeprobable ferredoxin--NADP(+) reductase7e-21102
NC_014541:1996811:1999529199952920036294101Ferrimonas balearica DSM 9799 chromosome, complete genomeformate dehydrogenase, alpha subunit1e-1067.8
NC_015318:219484:2262582262582276731416Hippea maritima DSM 10411 chromosome, complete genomeglutamate synthase2e-1067.4
NC_014220:2102000:2110003211000321114061404Syntrophothermus lipocalidus DSM 12680 chromosome, complete genomeglutamate synthase (NADPH), homotetrameric2e-0964.3
NC_011766:75500:8683986839882511413Desulfurococcus kamchatkensis 1221n chromosome, complete genomeFerredoxin:NADP oxidoreductase, alpha subunit2e-0964.3
NC_012804:816961:8324138324138338611449Thermococcus gammatolerans EJ3, complete genomeGlutamate synthase (NADPH), homotetrameric (gltA)2e-0963.9
NC_013926:71186:8246082460838901431Aciduliprofundum boonei T469 chromosome, complete genomeglutamate synthase (NADPH), homotetrameric4e-0963.2
NC_009922:315870:3272743272743308523579Alkaliphilus oremlandii OhILAs, complete genomemolybdopterin oxidoreductase6e-0962.4
NC_015474:1432065:1434056143405614354831428Pyrococcus sp. NA2 chromosome, complete genomeputative oxidoreductase1e-0861.6
NC_013517:2437574:2481717248171724831651449Sebaldella termitidis ATCC 33386, complete genomeglutamate synthase, NADH/NADPH, small subunit1e-0861.2
NC_015389:2030154:2046206204620620476121407Coriobacterium glomerans PW2 chromosome, complete genomesulfide dehydrogenase (flavoprotein) subunit SudA3e-0860.1
NC_013740:2141523:2156599215659921584341836Acidaminococcus fermentans DSM 20731, complete genomeFAD-dependent pyridine nucleotide-disulphide oxidoreductase4e-0859.7
NC_009051:1242351:1263581126358112649241344Methanoculleus marisnigri JR1, complete genomeglutamate synthase (NADPH), homotetrameric5e-0859.3
NC_014915:1376035:1385025138502513864221398Geobacillus sp. Y412MC52 chromosome, complete genomeFAD-dependent pyridine nucleotide-disulfide oxidoreductase1e-0758.2
NC_013411:2236166:2245081224508122464781398Geobacillus sp. Y412MC61, complete genomeFAD-dependent pyridine nucleotide-disulphide oxidoreductase1e-0758.2
NC_016593:1527456:1536454153645415378511398Geobacillus thermoleovorans CCB_US3_UF5 chromosome, completeFAD-dependent pyridine nucleotide-disulfide oxidoreductase1e-0758.2
NC_006510:1446490:1455459145545914568081350Geobacillus kaustophilus HTA426, complete genomeglutamate synthasemall subunit1e-0758.2
NC_017243:685783:7012327012327025901359Brachyspira intermedia PWS/A chromosome, complete genomeglutamate synthase (DPH)1e-0758.2
NC_007519:1244198:1263741126374112651711431Desulfovibrio alaskensis G20 chromosome, complete genomeputative oxidoreductase2e-0757.8
NC_007802:224470:2446812446812461171437Jannaschia sp. CCS1, complete genomeglutamate synthase, small subunit2e-0757.8
NC_015975:441580:4595664595664609991434Lactobacillus ruminis ATCC 27782 chromosome, complete genomeglutamate synthase small subunit2e-0757.4
NC_002967:2194829:2198193219819322009372745Treponema denticola ATCC 35405, complete genomepyridine nucleotide-disulphide oxidoreductase family protein2e-0757.4
NC_012778:207415:2241192241192259661848Eubacterium eligens ATCC 27750, complete genomeglutamate synthase (NADPH) small chain3e-0757
NC_015410:617020:6362736362736376911419Pseudomonas mendocina NK-01 chromosome, complete genomeglutamate synthase subunit beta4e-0756.6
NC_010674:3141228:3147957314795731493481392Clostridium botulinum B str. Eklund 17B, complete genomeglutamate synthase (NADPH), homotetrameric4e-0756.6
NC_019977:468568:4854424854424868151374Methanomethylovorans hollandica DSM 15978, complete genomeNADPH-dependent glutamate synthase, homotetrameric4e-0756.6
NC_010001:1917456:1921125192112519238002676Clostridium phytofermentans ISDg, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein6e-0755.8
NC_010520:3580000:3592070359207035934551386Clostridium botulinum A3 str. Loch Maree, complete genomeglutamate synthase (NADPH), homotetrameric7e-0755.5
NC_016051:1803880:1827231182723118286461416Thermococcus sp. AM4 chromosome, complete genomeglutamate synthase (NADPH), homotetrameric8e-0755.5
NC_015958:1983815:1995178199517819965781401Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomeglutamate synthase (NADPH), homotetrameric8e-0755.5
NC_009439:574437:5940305940305954481419Pseudomonas mendocina ymp, complete genomeglutamate synthase subunit beta8e-0755.5
NC_015958:2527376:2544925254492525463251401Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomeglutamate synthase (NADPH), homotetrameric9e-0755.5
NC_015376:2241000:2242392224239222437291338Burkholderia gladioli BSR3 chromosome chromosome 2, completeNADPH-dependent glutamate synthase beta chain1e-0654.7
NC_010321:244371:2462642462642476641401Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completeglutamate synthase1e-0654.7
NC_009434:608765:6302716302716317401470Pseudomonas stutzeri A1501, complete genomeglutamate synthase subunit beta1e-0654.7
NC_016887:55000:6000160001614701470Nocardia cyriacigeorgica GUH-2, complete genomeglutamate synthase subunit beta2e-0654.3
NC_021182:1473535:1485392148539214867741383Clostridium pasteurianum BC1, complete genomeNADPH-dependent glutamate synthase, homotetrameric2e-0654.3
NC_016584:4601645:4610946461094646154154470Desulfosporosinus orientis DSM 765 chromosome, complete genomeNADPH-dependent glutamate synthase subunit beta-like oxidoreductase2e-0653.9
NC_009437:685214:6903426903426938783537Caldicellulosiruptor saccharolyticus DSM 8903, complete genomemolybdopterin oxidoreductase2e-0653.9
NC_012563:3729817:3756940375694037583221383Clostridium botulinum A2 str. Kyoto, complete genomeglutamate synthase (NADPH), homotetrameric3e-0653.9
NC_009495:3502000:3514866351486635162511386Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeoxidoreductase3e-0653.5
NC_009697:3463736:3490854349085434922391386Clostridium botulinum A str. ATCC 19397 chromosome, completeoxidoreductase3e-0653.5
NC_015740:636667:6571536571536585711419Pseudomonas stutzeri ATCC 17588 = LMG 11199 chromosome, completeglutamate synthase subunit beta3e-0653.5
NC_014472:294775:2992922992923007581467Flavobacteriales bacterium HTCC2170 chromosome, complete genomeNADPH-dependent glutamate synthase, small subunit3e-0653.5
NC_009699:3581376:3608500360850036098821383Clostridium botulinum F str. Langeland chromosome, complete genomeoxidoreductase3e-0653.5
NC_017297:3594000:3607115360711536084971383Clostridium botulinum F str. 230613 chromosome, complete genomeglutamate synthase (NADPH), homotetrameric3e-0653.5
NC_014829:1475000:1482700148270014840581359Bacillus cellulosilyticus DSM 2522 chromosome, complete genomeFAD-dependent pyridine nucleotide-disulfide oxidoreductase3e-0653.5
NC_014972:1510914:1534472153447215378523381Desulfobulbus propionicus DSM 2032 chromosome, complete genomeFAD-dependent pyridine nucleotide-disulfide oxidoreductase4e-0653.1
NC_012490:43000:6702767027684781452Rhodococcus erythropolis PR4, complete genomeglutamate synthase small subunit6e-0652.8
NC_010320:671699:6777206777206791201401Thermoanaerobacter sp. X514 chromosome, complete genomeglutamate synthase5e-0652.8
NC_011886:1891077:1897137189713718985941458Arthrobacter chlorophenolicus A6, complete genomeglutamate synthase, NADH/NADPH, small subunit5e-0652.8
NC_009464:251550:2563162563162577161401Uncultured methanogenic archaeon RC-I, complete genomeNADPH-dependent glutamate synthase, small subunit5e-0652.8
NC_013929:7663631:7674356767435676758911536Streptomyces scabiei 87.22 chromosome, complete genomeoxidoreductase6e-0652.4
NC_018531:1900619:1905225190522519066821458Arthrobacter sp. Rue61a chromosome, complete genomeglutamate synthase [NADPH/NADH], beta subunit7e-0652.4
NC_015499:119200:1267031267031281691467Thermodesulfobium narugense DSM 14796 chromosome, complete genomeglutamate synthase, NADH/NADPH, small subunit8e-0652.4
NC_014393:3650957:3656805365680536581781374Clostridium cellulovorans 743B chromosome, complete genomeglutamate synthase (NADPH), homotetrameric1e-0552