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Query: NC_000962:1095078:1108578 Mycobacterium tuberculosis H37Rv, complete genome

Start: 1108578, End: 1109171, Length: 594

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain has been derived from the original human-lung H37 isolate in 1934, and has been used extensively worldwide in biomedical research. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:1095753:110926511092651109858594Mycobacterium tuberculosis RGTB327 chromosome, complete genome5-formyltetrahydrofolate cyclo-ligase1e-78292
NC_016768:3296478:329953032995303300123594Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein1e-78292
NC_009525:1096386:110988611098861110479594Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein1e-78292
NC_009565:1098847:111234611123461112939594Mycobacterium tuberculosis F11, complete genomehypothetical protein1e-78292
NC_012943:3299744:330271833027183303389672Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein1e-78291
NC_015848:1105892:111938511193851119978594Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein4e-78290
NC_002945:1095337:110902911090291109622594Mycobacterium bovis AF2122/97, complete genomehypothetical protein4e-78290
NC_016804:1095846:110934611093461109939594Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein1e-77288
NC_012207:1097228:111072811107281111321594Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein1e-77288
NC_002755:1095105:110861711086171109204588Mycobacterium tuberculosis CDC1551, complete genome5-formyltetrahydrofolate cyclo-ligase-related protein1e-77288
NC_008769:1125567:113906711390671139660594Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein1e-77288
NC_017186:9120711:915257691525769153166591Amycolatopsis mediterranei S699 chromosome, complete genome5-formyltetrahydrofolate cyclo-ligase8e-26116
NC_006361:5146000:517259151725915173193603Nocardia farcinica IFM 10152, complete genomehypothetical protein4e-25114
NC_014168:471000:488006488006488560555Segniliparus rotundus DSM 44985 chromosome, complete genome5-formyltetrahydrofolate cyclo-ligase7e-1477
NC_012669:1011473:101147310114731012099627Beutenbergia cavernae DSM 12333, complete genome5-formyltetrahydrofolate cyclo-ligase7e-1373.6
NC_021064:1789980:181008418100841810704621Propionibacterium avidum 44067, complete genome5-formyltetrahydrofolate cyclo-ligase8e-1270.1
NC_014246:536338:558892558892559539648Mobiluncus curtisii ATCC 43063 chromosome, complete genome5-formyltetrahydrofolate cyclo-ligase5e-1167.8
NC_014221:266638:270898270898271458561Truepera radiovictrix DSM 17093 chromosome, complete genome5-formyltetrahydrofolate cyclo-ligase2e-0755.8
NC_015160:2521849:252184925218492522382534Odoribacter splanchnicus DSM 20712 chromosome, complete genome5-formyltetrahydrofolate cyclo-ligase1e-0653.1
NC_013174:2163947:216394721639472164591645Jonesia denitrificans DSM 20603, complete genome5-formyltetrahydrofolate cyclo-ligase1e-0652.8
NC_013421:553193:578901578901579542642Pectobacterium wasabiae WPP163, complete genome5-formyltetrahydrofolate cyclo-ligase4e-0651.2
NC_010162:9727465:973004997300499730654606Sorangium cellulosum 'So ce 56', complete genomeputative 5-formyltetrahydrofolate cyclo-ligase5e-0650.8
NC_002946:1935186:195353919535391954198660Neisseria gonorrhoeae FA 1090, complete genomehypothetical protein9e-0650.1
NC_011035:1876555:187905618790561879700645Neisseria gonorrhoeae NCCP11945 chromosome, complete genomehypothetical protein1e-0550.1