Pre_GI: BLASTP Hits

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Query: NC_000962:1095078:1106405 Mycobacterium tuberculosis H37Rv, complete genome

Start: 1106405, End: 1107382, Length: 978

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain has been derived from the original human-lung H37 isolate in 1934, and has been used extensively worldwide in biomedical research. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015848:1105892:111721211172121118189978Mycobacterium canettii CIPT 140010059, complete genomeputative polyprenyl-diphosphate synthase GRCC27e-160563
NC_009525:1096386:110771311077131108690978Mycobacterium tuberculosis H37Ra, complete genomepolyprenyl-diphosphate synthase GrcC23e-159561
NC_012207:1097228:110855511085551109532978Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative polyprenyl-diphosphate synthase5e-159560
NC_008769:1125567:113689411368941137871978Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative polyprenyl-diphosphate synthase grcC25e-159560
NC_002945:1095337:110685611068561107833978Mycobacterium bovis AF2122/97, complete genomepolyprenyl-diphosphate synthase5e-159560
NC_009565:1098847:111017311101731111150978Mycobacterium tuberculosis F11, complete genomepolyprenyl-diphosphate synthase grcC25e-159560
NC_012943:3299744:330458533045853305562978Mycobacterium tuberculosis KZN 1435 chromosome, complete genomepolyprenyl synthetase5e-159560
NC_016768:3296478:330131933013193302296978Mycobacterium tuberculosis KZN 4207 chromosome, complete genomepolyprenyl-diphosphate synthase grcC25e-159560
NC_016804:1095846:110717311071731108150978Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative polyprenyl-diphosphate synthase5e-159560
NC_017026:1095753:110709211070921108069978Mycobacterium tuberculosis RGTB327 chromosome, complete genomepolyprenyl synthetase5e-159560
NC_002755:1095105:1106444110644411074451002Mycobacterium tuberculosis CDC1551, complete genomepolyprenyl synthetase6e-158556
NC_017186:529024:5411775411775422291053Amycolatopsis mediterranei S699 chromosome, complete genometrans-hexaprenyltranstransferase8e-51201
NC_014318:529010:5411635411635422151053Amycolatopsis mediterranei U32 chromosome, complete genometrans-hexaprenyltranstransferase8e-51201
NC_013595:606096:607661607661608656996Streptosporangium roseum DSM 43021, complete genomeTrans-hexaprenyltranstransferase3e-46185
NC_006087:177375:1773751773751784361062Leifsonia xyli subsp. xyli str. CTCB07, complete genometrans-hexaprenyltranstransferase1e-28127
NC_015589:1630461:164634516463451647307963Desulfotomaculum ruminis DSM 2154 chromosome, complete genomePolyprenyl synthetase8e-27121
NC_014758:579741:584574584574585545972Calditerrivibrio nitroreducens DSM 19672 chromosome, completepolyprenyl synthetase2e-23109
NC_007644:1293701:129370112937011294669969Moorella thermoacetica ATCC 39073, complete genomeTrans-hexaprenyltranstransferase2e-22106
NC_007681:979815:989514989514990497984Methanosphaera stadtmanae DSM 3091, complete genomeIdsA1e-21103
NC_013716:4885776:488577648857764886747972Citrobacter rodentium ICC168, complete genomeoctaprenyl-diphosphate synthase1e-20100
NC_000909:762859:782858782858783841984Methanocaldococcus jannaschii DSM 2661, complete genomebifunctional short chain isoprenyl diphosphate synthase (idsA)6e-2098.6
NC_015574:1541613:155130015513001552286987Methanobacterium sp. SWAN-1 chromosome, complete genomeDimethylallyltranstransferase5e-2098.6
NC_013887:1287783:128914612891461290099954Methanocaldococcus sp. FS406-22 chromosome, complete genomePolyprenyl synthetase2e-1996.7
NC_015437:918614:933928933928934902975Selenomonas sputigena ATCC 35185 chromosome, complete genomeTrans-hexaprenyltranstransferase2e-1996.7
NC_008555:2597980:261984426198442620824981Listeria welshimeri serovar 6b str. SLCC5334, complete genomepolyprenyl synthetase3e-1996.3
NC_012880:3915500:393438239343823935353972Dickeya dadantii Ech703, complete genomeTrans-hexaprenyltranstransferase9e-1994.4
NC_003919:3396136:341224834122483413246999Xanthomonas axonopodis pv. citri str. 306, complete genomeoctaprenyl-diphosphate synthase2e-1893.2
NC_017316:2637707:266096826609682661954987Enterococcus faecalis OG1RF chromosome, complete genometrans-hexaprenyltranstransferase4e-1892.4
NC_004668:3118500:313830931383093139295987Enterococcus faecalis V583, complete genomeheptaprenyl diphosphate synthase, component II, putative3e-1892.4
NC_009012:686740:690963690963691919957Clostridium thermocellum ATCC 27405, complete genomeTrans-hexaprenyltranstransferase5e-1892
NC_013132:8732093:875318287531828754147966Chitinophaga pinensis DSM 2588, complete genomeTrans-hexaprenyltranstransferase1e-1790.9
NC_018080:5192264:521827352182735219241969Pseudomonas aeruginosa DK2 chromosome, complete genomeoctaprenyl-diphosphate synthase2e-1790.5
NC_008463:5364428:538933053893305390298969Pseudomonas aeruginosa UCBPP-PA14, complete genomeoctylprenyl diphosphate synthase2e-1790.5
NC_010170:4463000:4468177446817744692141038Bordetella petrii, complete genomeputative octaprenyl-diphosphate synthase4e-1789
NC_011725:1486635:149869814986981499660963Bacillus cereus B4264 chromosome, complete genomeheptaprenyl diphosphate synthase component II5e-1788.6
NC_007940:782207:7968007968007978041005Rickettsia bellii RML369-C, complete genomeOctaprenyl-diphosphate synthase1e-1687.8
NC_009883:871594:885181885181886164984Rickettsia bellii OSU 85-389, complete genomeOctaprenyl-diphosphate synthase9e-1787.8
NC_012559:2854640:287946228794622880430969Laribacter hongkongensis HLHK9, complete genomeIspB5e-1685.5
NC_009727:1678568:167856816785681679566999Coxiella burnetii Dugway 7E9-12, complete genomepolyprenyl synthetase family protein6e-1685.1
NC_014122:685701:707759707759708712954Methanocaldococcus infernus ME chromosome, complete genomePolyprenyl synthetase1e-1584.3
NC_014909:86000:105536105536106510975Candidatus Blochmannia vafer str. BVAF chromosome, complete genomeoctaprenyl-diphosphate synthase1e-1584.3
NC_003551:723901:735536735536736510975Methanopyrus kandleri AV19, complete genomeGeranylgeranyl pyrophosphate synthase1e-1584
NC_014507:758820:776197776197777162966Methanoplanus petrolearius DSM 11571 chromosome, complete genomepolyprenyl synthetase4e-1582.4
NC_008344:811386:841237841237842205969Nitrosomonas eutropha C91, complete genomeFarnesyltranstransferase6e-1582
NC_018678:554675:557114557114558088975Alteromonas macleodii str. 'English Channel 673' chromosome,geranylgeranyl pyrophosphate synthase6e-1581.6
NC_014532:349384:3610403610403620411002Halomonas elongata DSM 2581, complete genomeoctylprenyl diphosphate synthase7e-1581.6
NC_015682:150808:173406173406174392987Thermodesulfobacterium sp. OPB45 chromosome, complete genometrans-hexaprenyltranstransferase2e-1480.1
NC_007484:3429140:3429140342914034301771038Nitrosococcus oceani ATCC 19707, complete genomeTrans-hexaprenyltranstransferase2e-1480.1
NC_005125:760721:803020803020803997978Gloeobacter violaceus PCC 7421, complete genomesolanesyl diphosphate synthase3e-1479.3
NC_002754:46297:512075120752205999Sulfolobus solfataricus P2, complete genomeGeranylgeranyl pyrophosphate synthetase (gdS-1)4e-1479
NC_015380:859424:8731288731288741441017Candidatus Pelagibacter sp. IMCC9063 chromosome, complete genomeoctaprenyl-diphosphate synthase / Dimethylallyltransferase / Geranyltranstransferase (farnesyldiphosphate synthase) / Geranylgeranyl pyrophosphate syn4e-1479
NC_009515:1409912:146627614662761467268993Methanobrevibacter smithii ATCC 35061, complete genomebifunctional short chain isoprenyl diphosphate synthase, IdsA6e-1478.6
NC_014820:1618606:161860616186061619571966Cenarchaeum symbiosum A, complete genomegeranylgeranyl pyrophosphate synthase/geranyltranstransferase8e-1478.2
NC_020304:2107979:2123746212374621247741029Desulfocapsa sulfexigens DSM 10523, complete genomegeranylgeranyl pyrophosphate synthase9e-1477.8
NC_019977:1621939:162475016247501625715966Methanomethylovorans hollandica DSM 15978, complete genomegeranylgeranyl pyrophosphate synthase9e-1477.8
NC_011959:972798:9920129920129930161005Thermomicrobium roseum DSM 5159, complete genomeheptaprenyl diphosphate synthase component II1e-1377.8
NC_015571:260664:278322278322279296975Porphyromonas gingivalis TDC60, complete genomeputative polyprenyl synthetase1e-1377.8
NC_015144:2053969:205530220553022056279978Weeksella virosa DSM 16922 chromosome, complete genometrans-hexaprenyltranstransferase2e-1377
NC_010729:2147268:216593521659352166909975Porphyromonas gingivalis ATCC 33277, complete genomeputative polyprenyl synthetase2e-1376.6
NC_002950:2068500:208724120872412088119879Porphyromonas gingivalis W83, complete genomepolyprenyl synthetase3e-1375.9
NC_011979:1683964:169068416906841691652969Geobacter sp. FRC-32, complete genomePolyprenyl synthetase5e-1375.5
NC_016616:134449:166372166372167340969Dechlorosoma suillum PS chromosome, complete genomegeranylgeranyl pyrophosphate synthase6e-1375.5
NC_014374:318528:3281343281343291501017Acidilobus saccharovorans 345-15 chromosome, complete genomeFarnesylgeranyl diphosphate synthase2e-1273.6
NC_005061:96536:101185101185102159975Candidatus Blochmannia floridanus, complete genomeoctaprenyl-diphosphate synthase2e-1273.2
NC_015435:120334:132275132275133258984Metallosphaera cuprina Ar-4 chromosome, complete genomegeranyltranstransferase2e-1273.2
NC_015931:857327:868166868166869158993Pyrolobus fumarii 1A, complete genomepolyprenyl synthetase2e-1273.2
NC_014471:163404:1679261679261689661041Ignisphaera aggregans DSM 17230 chromosome, complete genomeDimethylallyltranstransferase3e-1272.8
NC_012589:2006323:201817020181702019165996Sulfolobus islandicus L.S.2.15, complete genomeFarnesyltranstransferase1e-1171.2
NC_012623:663020:668334668334669329996Sulfolobus islandicus Y.N.15.51 chromosome, complete genomefarnesyltranstransferase1e-1171.2
NC_012726:1878503:189035018903501891345996Sulfolobus islandicus M.16.4 chromosome, complete genomefarnesyltranstransferase1e-1171.2
NC_013769:1993557:200540420054042006399996Sulfolobus islandicus L.D.8.5 chromosome, complete genomefarnesyltranstransferase1e-1171.2
NC_020195:285606:290051290051291028978Blattabacterium sp. (Blatta orientalis) str. Tarazona, completeoctaprenyl diphosphate synthase9e-1271.2
NC_012622:1944544:195639119563911957386996Sulfolobus islandicus Y.G.57.14 chromosome, complete genomefarnesyltranstransferase9e-1271.2
NC_017192:497950:506291506291507190900Arcobacter sp. L, complete genomeoctaprenyl-diphosphate synthase9e-1271.2
NC_003106:2060628:206717820671782068167990Sulfolobus tokodaii str. 7, complete genomehypothetical geranylgeranyl pyrophosphate synthetase8e-1271.2
NC_012632:1980332:199218519921851993180996Sulfolobus islandicus M.16.27 chromosome, complete genomefarnesyltranstransferase1e-1170.9
NC_012588:1874242:188608918860891887084996Sulfolobus islandicus M.14.25 chromosome, complete genomefarnesyltranstransferase1e-1170.9
NC_017276:1772146:178399317839931784988996Sulfolobus islandicus REY15A chromosome, complete genomefarnesyltranstransferase1e-1170.9
NC_014774:171500:171502171502172470969Candidatus Liberibacter solanacearum CLso-ZC1 chromosome, completeoctaprenyl-diphosphate synthase protein2e-1170.5
NC_017275:1909403:192125119212511922246996Sulfolobus islandicus HVE10/4 chromosome, complete genomefarnesyltranstransferase1e-1170.5
NC_013741:1304000:132428413242841325267984Archaeoglobus profundus DSM 5631, complete genomeDimethylallyltranstransferase2e-1170.1
NC_007645:6049340:607702560770256077993969Hahella chejuensis KCTC 2396, complete genomeGeranylgeranyl pyrophosphate synthase2e-1170.1
NC_009074:3409849:341340334134033414395993Burkholderia pseudomallei 668 chromosome I, complete sequenceoctaprenyl-diphosphate synthase4e-1169.3
NC_015697:116000:137169137169138149981Lactobacillus reuteri SD2112 chromosome, complete genomepolyprenyl synthetase4e-1169.3
NC_018681:5490963:5501354550135455023911038Nocardia brasiliensis ATCC 700358 chromosome, complete genomeputative polyprenyl synthetase IDSB6e-1168.6
NC_007908:1328832:136121913612191362202984Rhodoferax ferrireducens T118, complete genomeFarnesyltranstransferase6e-1168.6
NC_010804:450130:467728467728468723996Burkholderia multivorans ATCC 17616 chromosome 1, completeheptaprenyl diphosphate synthase2e-1067
NC_010084:3051355:305605030560503057045996Burkholderia multivorans ATCC 17616 chromosome 1, completepolyprenyl synthetase2e-1067
NC_015518:614806:619451619451620431981Acidianus hospitalis W1 chromosome, complete genomefarnesyltranstransferase2e-1067
NC_007181:55685:694966949670488993Sulfolobus acidocaldarius DSM 639, complete genomegeranylgeranyl pyrophosphate synthetase5e-1065.5
NC_014910:966761:9828779828779839261050Alicycliphilus denitrificans BC chromosome, complete genomepolyprenyl synthetase1e-0963.9
NC_015422:910292:9281399281399291881050Alicycliphilus denitrificans K601 chromosome, complete genometrans-hexaprenyltranstransferase1e-0963.9
NC_019673:967559:974914974914975897984Saccharothrix espanaensis DSM 44229 complete genomeputative trans-hexaprenyltranstransferase2e-0963.5
NC_008782:867344:887111887111888094984Acidovorax sp. JS42, complete genomeDimethylallyltranstransferase2e-0963.5
NC_018876:863314:877396877396878361966Methanolobus psychrophilus R15 chromosome, complete genomefarnesyltranstransferase8e-0961.6
NC_000962:3781501:3797437379743737984891053Mycobacterium tuberculosis H37Rv, complete genomePOSSIBLE POLYPRENYL SYNTHETASE IDSB (POLYPRENYL TRANSFERASE) (POLYPRENYL DIPHOSPHATE SYNTHASE)7e-0961.6
NC_009525:3794000:3806560380656038076121053Mycobacterium tuberculosis H37Ra, complete genomeputative polyprenyl synthetase IdsB7e-0961.6
NC_002755:3773734:3788312378831237893761065Mycobacterium tuberculosis CDC1551, complete genomepolyprenyl synthetase1e-0860.8
NC_019950:3818000:382920138292013830154954Mycobacterium canettii CIPT 140060008 complete genomePutative polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase)1e-0860.8
NC_002945:3735141:3749720374972037507721053Mycobacterium bovis AF2122/97, complete genomepolyprenyl synthetase IdsB1e-0860.8
NC_008769:3769065:3783644378364437846961053Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative polyprenyl synthetase idsB1e-0860.8
NC_009565:3793976:3808554380855438096061053Mycobacterium tuberculosis F11, complete genomepolyprenyl synthetase idsB1e-0860.8
NC_012207:3766978:3781557378155737826091053Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative polyprenyl synthetase1e-0860.8
NC_012943:3777371:3791949379194937930011053Mycobacterium tuberculosis KZN 1435 chromosome, complete genomepolyprenyl synthetase1e-0860.8
NC_016768:3774105:3788683378868337897351053Mycobacterium tuberculosis KZN 4207 chromosome, complete genomepolyprenyl synthetase idsB1e-0860.8
NC_016804:3753243:3763009376300937640611053Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative polyprenyl synthetase1e-0860.8
NC_015848:3851230:3865810386581038668621053Mycobacterium canettii CIPT 140010059, complete genomeputative polyprenyl synthetase IDSB2e-0860.5
NC_013947:2113941:2118202211820221193081107Stackebrandtia nassauensis DSM 44728 chromosome, complete genomePolyprenyl synthetase3e-0859.7
NC_019977:828427:844786844786845685900Methanomethylovorans hollandica DSM 15978, complete genomegeranylgeranyl pyrophosphate synthase6e-0755.5
NC_012115:691154:710514710514711377864Nautilia profundicola AmH, complete genomeprenyl transferase6e-0755.1
NC_013422:1755875:180168718016871802616930Halothiobacillus neapolitanus c2, complete genomePolyprenyl synthetase7e-0755.1
NC_016582:11535695:1155335211553352115543651014Streptomyces bingchenggensis BCW-1 chromosome, complete genomepolyprenyl diphosphate synthase1e-0654.7
NC_017026:3754000:376668937666893767645957Mycobacterium tuberculosis RGTB327 chromosome, complete genomepolyprenyl synthetase1e-0653.9
NC_014219:2491021:249102124910212491914894Bacillus selenitireducens MLS10 chromosome, complete genomePolyprenyl synthetase2e-0653.9
NC_008553:329458:348426348426349295870Methanosaeta thermophila PT, complete genomePolyprenyl synthetase6e-0652